| Literature DB >> 33714675 |
Bernard Choi1, Christian Crouzet2, Wei Ling Lau3, David H Cribbs4, Mark J Fisher5.
Abstract
The prevalence of mild cognitive impairment increases with age and is further exacerbated by chronic kidney disease (CKD). CKD is associated with (1) mild cognitive impairment, (2) impaired endothelial function, (3) impaired blood-brain barrier, (4) increased cerebral microhemorrhage burden, (5) increased cerebral blood flow (CBF), (6) impaired cerebral autoregulation, (7) impaired cerebrovascular reactivity, and (8) increased arterial stiffness. We report preliminary findings from our group that demonstrate altered cerebrovascular reactivity in a mouse model of CKD-associated vascular calcification. The CBF of CKD mice increased more quickly in response to hypercapnia (p < 0.05) but then decreased prematurely during hypercapnia challenge (p < 0.05). Together, these results indicate that altered kidney function can lead to alterations in the cerebral microvasculature, and hence brain health.Entities:
Keywords: Cerebral blood flow; Chronic kidney disease; Laser speckle contrast imaging; Speckle contrast; Vascular dysfunction; Vasomotor reactivity
Mesh：
Year: 2021 PMID： 33714675 PMCID： PMC8384649 DOI： 10.1016/j.jstrokecerebrovasdis.2021.105702
Source DB: PubMed Journal: J Stroke Cerebrovasc Dis ISSN： 1052-3057 Impact factor: 2.677