Literature DB >> 33713792

Liver X receptors and liver physiology.

Lillian Russo-Savage1, Ira G Schulman2.   

Abstract

The liver x receptors LXRα (NR1H3) and LXRβ (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Studies using genetic knockouts and synthetic ligands have defined the LXRs as important modulators of lipid homeostasis throughout the body. This review focuses on the control of cholesterol and fatty acid metabolism by LXRs in the liver and how modifying LXR activity can influence the pathology of liver diseases.
Copyright © 2021. Published by Elsevier B.V.

Entities:  

Keywords:  Cholesterol; Fatty acids; LXR; Liver; NASH; Nuclear receptors

Mesh：

Substances：

Year:  2021        PMID： 33713792      PMCID： PMC9242550          DOI： 10.1016/j.bbadis.2021.166121

Source DB:  PubMed          Journal:  Biochim Biophys Acta Mol Basis Dis        ISSN： 0925-4439            Impact factor:   6.633


  154 in total

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3.  An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha.

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5.  Pharmacologic inhibition of phospholipid transfer protein activity reduces apolipoprotein-B secretion from hepatocytes.

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Journal:  J Pharmacol Exp Ther       Date:  2009-11-20       Impact factor: 4.030

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Authors:  Xiaobo Wang; Bishuang Cai; Xiaoming Yang; Oluwatoni O Sonubi; Ze Zheng; Rajasekhar Ramakrishnan; Hongxue Shi; Luca Valenti; Utpal B Pajvani; Jaspreet Sandhu; Rodney E Infante; Arun Radhakrishnan; Douglas F Covey; Kun-Liang Guan; Jochen Buck; Lonny R Levin; Peter Tontonoz; Robert F Schwabe; Ira Tabas
Journal:  Cell Metab       Date:  2020-04-06       Impact factor: 27.287

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8.  Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.

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Journal:  Immunity       Date:  2019-09-24       Impact factor: 31.745

9.  Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.

Authors:  Minako Ishibashi; Rodolphe Filomenko; Cédric Rébé; Angélique Chevriaux; Alexis Varin; Valentin Derangère; Ginette Bessède; Philippe Gambert; Laurent Lagrost; David Masson
Journal:  Biochem Pharmacol       Date:  2013-01-09       Impact factor: 5.858

Review 10.  An Evidence-Based Review of Statin Use in Patients With Nonalcoholic Fatty Liver Disease.

Authors:  Meredith A Sigler; Lee Congdon; Krystal L Edwards
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4.  Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat.

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  4 in total

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