| Literature DB >> 33713790 |
Alida Spalloni1, Silvia Caioli1, Elisa Bonomi2, Cristina Zona1, Emanuele Buratti3, Antonella Alberici4, Barbara Borroni2, Patrizia Longone5.
Abstract
Frontotemporal Lobar Degeneration (FTD) is a neurodegenerative disease characterized by a progressive deterioration of cognitive functions. Currently, no effective treatment exists. We have studied cytotoxicity and neuronal functionality in cortical and spinal cord cultures upon exposure to cerebrospinal fluid (CSF) from 39 FTD patients. FTD-CSF alters the miniature excitatory postsynaptic currents in the cortical cultures and it is toxic to spinal cord cultures, particularly to GABAergic+ and calbindin-D28k + neurons.Entities:
Keywords: Cerebrospinal fluid; Cytotoxicity; Frontotemporal dementia; Neuronal cell culture; Synaptic activity
Year: 2021 PMID： 33713790 DOI： 10.1016/j.bbadis.2021.166122
Source DB: PubMed Journal: Biochim Biophys Acta Mol Basis Dis ISSN： 0925-4439 Impact factor: 5.187