Literature DB >> 33713781

Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole.

Svetlana V Blokhina1, Angelica V Sharapova2, Marina V Ol'khovich1, Irina A Doroshenko3, Igor B Levshin4, German L Perlovich1.   

Abstract

Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity against filamentous and yeast fungi.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antifungal activity; Hybrids; Lipophilicity; Solubility; Thiazolo-pyrimidins; Triazole

Year:  2021        PMID： 33713781     DOI： 10.1016/j.bmcl.2021.127944

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Eco-friendly and regiospecific intramolecular cyclization reactions of cyano and carbonyl groups in N,N-disubstituted cyanamide.

Authors:  Amr H Moustafa; Walaa W Ahmed; Mohamed F Awad; Moustafa O Aboelez; Ahmed Khodairy; Amer A Amer
Journal:  Mol Divers       Date:  2022-02-27       Impact factor: 3.364

Review 2.  Novel 1, 2, 4-Triazoles as Antifungal Agents.

Authors:  Zahra Kazeminejad; Mahrokh Marzi; Abolfazl Shiroudi; Seyed Amin Kouhpayeh; Mojtaba Farjam; Elham Zarenezhad
Journal:  Biomed Res Int       Date:  2022-03-22       Impact factor: 3.411

3.  Experimental Examination of Solubility and Lipophilicity as Pharmaceutically Relevant Points of Novel Bioactive Hybrid Compounds.

Authors:  Angelica Sharapova; Marina Ol'khovich; Svetlana Blokhina; German L Perlovich
Journal:  Molecules       Date:  2022-10-01       Impact factor: 4.927
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.