Sakine Shirvalilou1, Samideh Khoei2,3, Azam Janati Esfahani4, Mahboobeh Kamali5, Milad Shirvaliloo6, Roghayeh Sheervalilou7, Parvin Mirzaghavami8. 1. Finetech in Medicine Research Center, Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, P.O. Box: 1449614525, Tehran, Iran. Sakine.shirvaliloo@gmail.com. 2. Finetech in Medicine Research Center, Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, P.O. Box: 1449614525, Tehran, Iran. khoei.s@iums.ac.ir. 3. Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. khoei.s@iums.ac.ir. 4. Department of Medical Biotechnology, School of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran. 5. Occupational Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran. 6. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. 7. Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. 8. Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract
INTRODUCTION: Hyperthermia therapy (HT) is a recognized treatment modality, that can sensitize tumors to the effects of radiotherapy (RT) and chemotherapy by heating up tumor cells to 40-45 °C. The advantages of noninvasive inductive magnetic hyperthermia (MH) over RT or chemotherapy in the treatment of recurrent/progressive glioma have been confirmed by several clinical trials. Thus, here we have conducted a systematic review to provide a concise, albeit brief, account of the currently available literature regarding this topic. METHODS: Five databases, PubMed/Medline, Embace, Ovid, WOS, and Scopus, were investigated to identify clinical studies comparing overall survival (OS) following RT/chemotherapy versus RT/chemotherapy + MH. RESULTS: Eleven articles were selected for this systematic review, including reports on 227 glioma patients who met the study inclusion criteria. The papers included in this review comprised nine pilot clinical trials, one non-randomized clinical trial, and one retrospective investigation. As the clinical trials suggested, MH improved OS in primary glioblastoma (GBM), however, in the case of recurrent glioblastoma, no significant change in OS was reported. All 11 studies ascertained that no major side effects were observed during MH therapy. CONCLUSION: Our systematic review indicates that MH therapy as an adjuvant for RT could result in improved survival, compared to the therapeutic outcomes achieved with RT alone in GBM, especially by intratumoral injection of magnetic nanoparticles. However, heterogeneity in the methodology of the most well-known studies, and differences in the study design may significantly limit the extent to which conclusions can be drawn. Thus, further investigations are required to shed more light on the efficacy of MH therapy as an adjuvant treatment modality in GBM.
INTRODUCTION: Hyperthermia therapy (HT) is a recognized treatment modality, that can sensitize tumors to the effects of radiotherapy (RT) and chemotherapy by heating up tumor cells to 40-45 °C. The advantages of noninvasive inductive magnetic hyperthermia (MH) over RT or chemotherapy in the treatment of recurrent/progressive glioma have been confirmed by several clinical trials. Thus, here we have conducted a systematic review to provide a concise, albeit brief, account of the currently available literature regarding this topic. METHODS: Five databases, PubMed/Medline, Embace, Ovid, WOS, and Scopus, were investigated to identify clinical studies comparing overall survival (OS) following RT/chemotherapy versus RT/chemotherapy + MH. RESULTS: Eleven articles were selected for this systematic review, including reports on 227 glioma patients who met the study inclusion criteria. The papers included in this review comprised nine pilot clinical trials, one non-randomized clinical trial, and one retrospective investigation. As the clinical trials suggested, MH improved OS in primary glioblastoma (GBM), however, in the case of recurrent glioblastoma, no significant change in OS was reported. All 11 studies ascertained that no major side effects were observed during MH therapy. CONCLUSION: Our systematic review indicates that MH therapy as an adjuvant for RT could result in improved survival, compared to the therapeutic outcomes achieved with RT alone in GBM, especially by intratumoral injection of magnetic nanoparticles. However, heterogeneity in the methodology of the most well-known studies, and differences in the study design may significantly limit the extent to which conclusions can be drawn. Thus, further investigations are required to shed more light on the efficacy of MH therapy as an adjuvant treatment modality in GBM.
Entities:
Keywords:
Clinical Trial; Glioma; Magnetic hyperthermia; Overall survival; Systematic Review
Authors: Klaus Maier-Hauff; Ronny Rothe; Regina Scholz; Uwe Gneveckow; Peter Wust; Burghard Thiesen; Annelie Feussner; Andreas von Deimling; Norbert Waldoefner; Roland Felix; Andreas Jordan Journal: J Neurooncol Date: 2006-06-14 Impact factor: 4.130
Authors: Oliver Grauer; Mohammed Jaber; Katharina Hess; Matthias Weckesser; Wolfram Schwindt; Stephan Maring; Johannes Wölfer; Walter Stummer Journal: J Neurooncol Date: 2018-12-01 Impact factor: 4.130