Stefan Sponholz1, Selma Oguzhan2, Mesut Mese2, Moritz Schirren3, Andreas Kirschbaum4, Joachim Schirren2. 1. Department of Thoracic Surgery, Agaplesion Markus Krankenhaus, Wilhelm-Epstein-Str. 4, 60431, Frankfurt, Germany. Stefan.sponholz@fdk.info. 2. Department of Thoracic Surgery, Agaplesion Markus Krankenhaus, Wilhelm-Epstein-Str. 4, 60431, Frankfurt, Germany. 3. Department of Thoracic Surgery, Klinikum rechts der Isar der Technischen Universität, München, Germany. 4. Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Gießen und Marburg (UKGM), Campus, Marburg, Germany.
Abstract
PURPOSE: Currently, right colon cancer (RCC), left colon cancer (LCC), and rectal cancer (REC) are typically seen as different tumor entities. It is unknown if this subdivision by primary tumor location has an influence on the survival of patients with colorectal pulmonary metastasectomy (PM). METHODS: We retrospectively analyzed our prospective database of 233 patients operated on for colorectal lung metastases between 1999 and 2014. Differences in the patient characteristics and the primary tumor and metastatic tumor burden were analyzed using χ2-tests. The long-term survival after PM of the three groups was analyzed with the Kaplan-Meier method and log-rank tests. RESULTS: In total, PM was performed for 37 patients with RCC, 57 patients with LCC, and 139 patients with REC. Patients with LCC were significantly more likely to have UICC stage IV primary tumor (44.2% LCC vs. 37.5% RCC vs. 22.8% REC, p = 0.012) and significantly more likely to have a history of additional liver metastases (45.6% LCC vs. 32.4% RCC vs. 27.3% REC, p = 0.046). The 5-year survival rates after PM for patients with RCC, LCC, and REC were 47, 66, and 39%, respectively (p = 0.001). The median survival times of patients with RCC, LCC, and REC were 55 months (95% CI: 42.2-66.8), 108 months (95% CI: 52.7-163.3), and 44 months (95% CI: 50.4-63.6), respectively. CONCLUSIONS: This study demonstrated a prognostic impact of the primary tumor localization in patients undergoing PM for colorectal lung metastases. Nevertheless, long-term survival was achievable in all groups.
PURPOSE: Currently, right colon cancer (RCC), left colon cancer (LCC), and rectal cancer (REC) are typically seen as different tumor entities. It is unknown if this subdivision by primary tumor location has an influence on the survival of patients with colorectal pulmonary metastasectomy (PM). METHODS: We retrospectively analyzed our prospective database of 233 patients operated on for colorectal lung metastases between 1999 and 2014. Differences in the patient characteristics and the primary tumor and metastatic tumor burden were analyzed using χ2-tests. The long-term survival after PM of the three groups was analyzed with the Kaplan-Meier method and log-rank tests. RESULTS: In total, PM was performed for 37 patients with RCC, 57 patients with LCC, and 139 patients with REC. Patients with LCC were significantly more likely to have UICC stage IV primary tumor (44.2% LCC vs. 37.5% RCC vs. 22.8% REC, p = 0.012) and significantly more likely to have a history of additional liver metastases (45.6% LCC vs. 32.4% RCC vs. 27.3% REC, p = 0.046). The 5-year survival rates after PM for patients with RCC, LCC, and REC were 47, 66, and 39%, respectively (p = 0.001). The median survival times of patients with RCC, LCC, and REC were 55 months (95% CI: 42.2-66.8), 108 months (95% CI: 52.7-163.3), and 44 months (95% CI: 50.4-63.6), respectively. CONCLUSIONS: This study demonstrated a prognostic impact of the primary tumor localization in patients undergoing PM for colorectal lung metastases. Nevertheless, long-term survival was achievable in all groups.
Authors: Julian Walter Holch; Ingrid Ricard; Sebastian Stintzing; Dominik Paul Modest; Volker Heinemann Journal: Eur J Cancer Date: 2016-11-29 Impact factor: 9.162
Authors: Robert A Meguid; Mark B Slidell; Christopher L Wolfgang; David C Chang; Nita Ahuja Journal: Ann Surg Oncol Date: 2008-07-12 Impact factor: 5.344
Authors: Michel Gonzalez; Antoine Poncet; Christophe Combescure; John Robert; Hans Beat Ris; Pascal Gervaz Journal: Ann Surg Oncol Date: 2012-10-28 Impact factor: 5.344
Authors: Nelleke P M Brouwer; Dave E W van der Kruijssen; Niek Hugen; Ignace H J T de Hingh; Iris D Nagtegaal; Rob H A Verhoeven; Miriam Koopman; Johannes H W de Wilt Journal: Ann Surg Oncol Date: 2019-12-02 Impact factor: 5.344
Authors: G Meimarakis; F Spelsberg; M Angele; G Preissler; J Fertmann; A Crispin; S Reu; N Kalaitzis; M Stemmler; C Giessen; V Heinemann; S Stintzing; R Hatz; H Winter Journal: Ann Surg Oncol Date: 2014-03-26 Impact factor: 5.344
Authors: Jae Ho Byun; Joong Bae Ahn; Sun Young Kim; Jung Hun Kang; Dae Young Zang; Seok Yun Kang; Myoung Joo Kang; Byoung Yong Shim; Sun Kyung Baek; Bong-Seog Kim; Kyung Hee Lee; Soon Il Lee; Sang-Hee Cho; Byeong Seok Sohn; Samyong Kim; In Gyu Hwang; Eun Mi Nam; Bong-Gun Seo; Sang Cheul Oh; Myung-Ah Lee; Sang-Cheol Lee; Ji Hyung Hong; Young Suk Park Journal: Korean J Intern Med Date: 2017-11-28 Impact factor: 2.884