Xin-Ni Lv1, Lan Deng1, Wen-Song Yang1, Xiao Wei2, Qi Li3. 1. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. 2. Department of Traditional Chinese Medicine, Chongqing Medical and Pharmaceutical College, Chongqing, 401331, China. 1259446388@qq.com. 3. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. qili_md@126.com.
Abstract
PURPOSE OF REVIEW: Hematoma expansion (HE) is strongly associated with poor clinical outcome and is a compelling target for improving outcome after intracerebral hemorrhage (ICH). Non-contrast computed tomography (NCCT) is widely used in clinical practice due to its faster acquisition at the presence of acute stroke. Recently, imaging markers on NCCT are increasingly used for predicting HE. We comprehensively review the current evidence on HE prediction using NCCT and provide a summary for assessment of these markers in future research studies. RECENT FINDINGS: Predictors of HE on NCCT have been described in reports of several studies. The proposed markers, including swirl sign, blend sign, black hole sign, island sign, satellite sign, and subarachnoid extension, were all significantly associated with HE and poor outcome in their small sample studies after ICH. In summary, the optimal management of ICH remains a therapeutic dilemma. Therefore, using NCCT markers to select patients at high risk of HE is urgently needed. These markers may allow rapid identification and provide potential targets for anti-HE treatments in patients with acute ICH.
PURPOSE OF REVIEW: Hematoma expansion (HE) is strongly associated with poor clinical outcome and is a compelling target for improving outcome after intracerebral hemorrhage (ICH). Non-contrast computed tomography (NCCT) is widely used in clinical practice due to its faster acquisition at the presence of acute stroke. Recently, imaging markers on NCCT are increasingly used for predicting HE. We comprehensively review the current evidence on HE prediction using NCCT and provide a summary for assessment of these markers in future research studies. RECENT FINDINGS: Predictors of HE on NCCT have been described in reports of several studies. The proposed markers, including swirl sign, blend sign, black hole sign, island sign, satellite sign, and subarachnoid extension, were all significantly associated with HE and poor outcome in their small sample studies after ICH. In summary, the optimal management of ICH remains a therapeutic dilemma. Therefore, using NCCT markers to select patients at high risk of HE is urgently needed. These markers may allow rapid identification and provide potential targets for anti-HE treatments in patients with acute ICH.
Authors: Javier M Romero; H Bart Brouwers; Jingjing Lu; Josser E Delgado Almandoz; Hillary Kelly; Jeremy Heit; Joshua Goldstein; Jonathan Rosand; R Gilberto Gonzalez Journal: Stroke Date: 2013-09-10 Impact factor: 7.914
Authors: Gregoire Boulouis; Andrea Morotti; H Bart Brouwers; Andreas Charidimou; Michael J Jessel; Eitan Auriel; Octávio Pontes-Neto; Alison Ayres; Anastasia Vashkevich; Kristin M Schwab; Jonathan Rosand; Anand Viswanathan; Mahmut E Gurol; Steven M Greenberg; Joshua N Goldstein Journal: JAMA Neurol Date: 2016-08-01 Impact factor: 18.302
Authors: J N Goldstein; L E Fazen; R Snider; K Schwab; S M Greenberg; E E Smith; M H Lev; J Rosand Journal: Neurology Date: 2007-03-20 Impact factor: 9.910
Authors: Ryan Wada; Richard I Aviv; Allan J Fox; Demetrios J Sahlas; David J Gladstone; George Tomlinson; Sean P Symons Journal: Stroke Date: 2007-02-22 Impact factor: 7.914
Authors: H Bart Brouwers; Yuchiao Chang; Guido J Falcone; Xuemei Cai; Alison M Ayres; Thomas W K Battey; Anastasia Vashkevich; Kristen A McNamara; Valerie Valant; Kristin Schwab; Susannah C Orzell; Linda M Bresette; Steven K Feske; Natalia S Rost; Javier M Romero; Anand Viswanathan; Sherry H-Y Chou; Steven M Greenberg; Jonathan Rosand; Joshua N Goldstein Journal: JAMA Neurol Date: 2014-02 Impact factor: 18.302
Authors: Candice Delcourt; Yining Huang; Hisatomi Arima; John Chalmers; Stephen M Davis; Emma L Heeley; Jiguang Wang; Mark W Parsons; Guorong Liu; Craig S Anderson Journal: Neurology Date: 2012-06-27 Impact factor: 9.910
Authors: Valery L Feigin; Gregory A Roth; Mohsen Naghavi; Priya Parmar; Rita Krishnamurthi; Sumeet Chugh; George A Mensah; Bo Norrving; Ivy Shiue; Marie Ng; Kara Estep; Kelly Cercy; Christopher J L Murray; Mohammad H Forouzanfar Journal: Lancet Neurol Date: 2016-06-09 Impact factor: 44.182