| Literature DB >> 33710023 |
Thomas L Nickolas1, Jonathan Barasch1, Kenneth K Mugwanya2, Andrea D Branch3, Renee Heffron2,4, Valentine Wanga2, Nelly R Mugo2,5, Allan Ronald6, Connie Celum2,7, Deborah Donnell2, Jared M Baeten2,4,7, Christina M Wyatt8.
Abstract
We previously reported a higher incidence of non-albumin proteinuria and a small but significant decline in estimated glomerular filtration rate (eGFR) among HIV-negative adults randomized to emtricitabine/tenofovir disoproxil fumarate preexposure prophylaxis (FTC/TDF PrEP) versus placebo. In a nested case--control study among participants randomized to FTC/TDF PrEP, established kidney injury biomarkers measured at 12 months were not significantly different between participants who subsequently experienced one of these kidney endpoints and randomly selected controls who did not.Entities:
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Year: 2021 PMID: 33710023 PMCID: PMC8102362 DOI: 10.1097/QAD.0000000000002865
Source DB: PubMed Journal: AIDS ISSN: 0269-9370 Impact factor: 4.632