Finja Schweitzer1, Nina N Kleineberg1,2, Yasemin Göreci1, Oezguer A Onur1,2, Christiana Franke3, Clemens Warnke1. 1. Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne. 2. Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich. 3. Department of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Abstract
PURPOSE OF REVIEW: To provide an overview on current knowledge of neurological symptoms and complications of COVID-19, and to suggest management concepts. RECENT FINDINGS: Headache, dizziness, excessive tiredness, myalgia, anosmia/hyposmia, and ageusia/dysgeusia are common nonspecific neurological manifestations during early COVID-19 disease found in the majority of patients. Less frequent but more severe and specific neurological manifestations include Guillain--Barré syndrome, encephalopathy, encephalitis/meningitis, epileptic seizures, and cerebrovascular events. Beyond standard neurological examination, these require a more extensive work-up, including cerebrospinal fluid assessment, neurophysiological evaluation, neuroimaging, and cognitive testing. Symptomatic treatment is advisable unless the neurological complication's immune pathogenesis is proven. SUMMARY: Neurological manifestations of COVID-19 occur during the acute, para-infectious, and 'recovery' phase. Therapeutic management depends on the clinical presentation and neurological work-up.
PURPOSE OF REVIEW: To provide an overview on current knowledge of neurological symptoms and complications of COVID-19, and to suggest management concepts. RECENT FINDINGS:Headache, dizziness, excessive tiredness, myalgia, anosmia/hyposmia, and ageusia/dysgeusia are common nonspecific neurological manifestations during early COVID-19 disease found in the majority of patients. Less frequent but more severe and specific neurological manifestations include Guillain--Barré syndrome, encephalopathy, encephalitis/meningitis, epileptic seizures, and cerebrovascular events. Beyond standard neurological examination, these require a more extensive work-up, including cerebrospinal fluid assessment, neurophysiological evaluation, neuroimaging, and cognitive testing. Symptomatic treatment is advisable unless the neurological complication's immune pathogenesis is proven. SUMMARY: Neurological manifestations of COVID-19 occur during the acute, para-infectious, and 'recovery' phase. Therapeutic management depends on the clinical presentation and neurological work-up.
Authors: Nina N Kleineberg; Samuel Knauss; Eileen Gülke; Hans O Pinnschmidt; Carolin E M Jakob; Paul Lingor; Kerstin Hellwig; Achim Berthele; Günter Höglinger; Gereon R Fink; Matthias Endres; Christian Gerloff; Christine Klein; Melanie Stecher; Annika Y Classen; Siegbert Rieg; Stefan Borgmann; Frank Hanses; Maria M Rüthrich; Martin Hower; Lukas Tometten; Martina Haselberger; Christiane Piepel; Uta Merle; Sebastian Dolff; Christian Degenhardt; Björn-Erik O Jensen; Maria J G T Vehreschild; Johanna Erber; Christiana Franke; Clemens Warnke Journal: Eur J Neurol Date: 2021-09-03 Impact factor: 6.288
Authors: Antonio L Teixeira; Trudy Millard Krause; Lopita Ghosh; Lokesh Shahani; Rodrigo Machado-Vieira; Scott D Lane; Eric Boerwinkle; Jair C Soares Journal: JAMA Netw Open Date: 2021-11-01
Authors: Finja Schweitzer; Yasemin Goereci; Veronica Di Cristanziano; Clemens Warnke; Christiana Franke; Steffi Silling; Fabian Bösl; Franziska Maier; Eva Heger; Birgit Deiman; Harald Prüss; Oezguer A Onur; Florian Klein; Gereon R Fink Journal: Ann Neurol Date: 2021-11-22 Impact factor: 11.274