| Literature DB >> 33709463 |
Rosa Rademakers1,2,3, Alexandra M Nicholson1, Yingxue Ren4, Shunsuke Koga1, Hung Phuoc Nguyen1, Mieu Brooks1, Wenhui Qiao1, Zachary S Quicksall4, Billie Matchett1, Ralph B Perkerson1, Aishe Kurti1, Monica Castanedes-Casey1, Virginia Phillips1, Ariston L Librero1, Cristhoper H Fernandez De Castro1, Matthew C Baker1, Shanu F Roemer1, Melissa E Murray1, Yan Asmann4, John D Fryer1, Guojun Bu1, Dennis W Dickson1, Xiaolai Zhou1,5.
Abstract
TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss.Entities:
Year: 2021 PMID： 33709463 DOI： 10.1111/bpa.12945
Source DB: PubMed Journal: Brain Pathol ISSN： 1015-6305 Impact factor: 6.508