Literature DB >> 33709305

Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review.

Liam Robinson1, Ciska-Mari Schouwstra1, Willie F P van Heerden2.   

Abstract

Primary mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) of the head and neck region is a rare biphasic tumor with an aggressive biological behavior. This report highlights an additional case of oropharyngeal MiNEN in a 46-year-old male patient with a previous long-term smoking history. Histologic evaluation revealed a biphasic tumor infiltrating the lamina propria. The first component consisted of a classic keratinizing squamous cell carcinoma. The second component consisted of small-to-intermediate sized cells with neuroendocrine features. Synaptophysin and CD56 immunohistochemical stains confirmed neuroendocrine lineage in this component. The presence of two morphological components with neuroendocrine and nonneuroendocrine features on histologic assessment should alert the pathologist to consider a MiNEN in their case work-up.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Biphasic tumor; Immunohistochemistry; Mixed neuroendocrine-nonneuroendocrine neoplasm; Molecular pathology; Oropharynx

Mesh：

Substances：

Year:  2021        PMID： 33709305      PMCID： PMC8633187          DOI： 10.1007/s12105-021-01312-w

Source DB:  PubMed          Journal:  Head Neck Pathol        ISSN： 1936-055X


  16 in total

1.  p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas.

Authors:  Llucia Alos; Sofia Hakim; Ana-Belen Larque; Jorge de la Oliva; Leonardo Rodriguez-Carunchio; Miguel Caballero; Alfons Nadal; Carles Marti; Nuria Guimera; Maria-Teresa Fernandez-Figueras; Wim Quint; Jaume Ordi
Journal:  Virchows Arch       Date:  2016-07-08       Impact factor: 4.064

Review 2.  Primary combined squamous and small cell carcinoma of the larynx: Report of two cases and discussion of treatment modalities.

Authors:  Annelore Barbeaux; Lionel Duck; Birgit Weynand; Gauthier Desuter; Marc Hamoir; Vincent Gregoire; Jean-François Baurain; Jean-Pascal Machiels
Journal:  Eur Arch Otorhinolaryngol       Date:  2006-05-23       Impact factor: 2.503

Review 3.  Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.

Authors:  Stefano La Rosa; Fausto Sessa; Silvia Uccella
Journal:  Endocr Pathol       Date:  2016-12       Impact factor: 3.943

Review 4.  Primary combined small cell carcinoma of larynx with lateralized histologic components and corresponding side-specific neck nodal metastasis: report of a unique case and review of literature.

Authors:  Gitika Aggarwal; Lana Jackson; Suash Sharma
Journal:  Int J Clin Exp Pathol       Date:  2010-12-03

Review 5.  The grey zone between pure (neuro)endocrine and non-(neuro)endocrine tumours: a comment on concepts and classification of mixed exocrine-endocrine neoplasms.

Authors:  Marco Volante; Guido Rindi; Mauro Papotti
Journal:  Virchows Arch       Date:  2006-10-11       Impact factor: 4.064

6.  Human papillomavirus-related small cell carcinoma of the oropharynx.

Authors:  Justin A Bishop; William H Westra
Journal:  Am J Surg Pathol       Date:  2011-11       Impact factor: 6.394

7.  Primary combined neuroendocrine and squamous cell carcinoma of the maxillary sinus: report of a case with immunohistochemical and molecular characterization.

Authors:  Alessandro Franchi; Davide Rocchetta; Annarita Palomba; Duccio Rossi Degli Innocenti; Francesca Castiglione; Giuseppe Spinelli
Journal:  Head Neck Pathol       Date:  2013-12-11

8.  Neuroendocrine Carcinomas of the Larynx and Head and Neck: Challenges in Classification and Grading.

Authors:  Bayardo Perez-Ordoñez
Journal:  Head Neck Pathol       Date:  2018-03-20

Review 9.  Mixed exocrine-neuroendocrine carcinoma of the nasal cavity: clinico-pathologic and molecular study of a case and review of the literature.

Authors:  Stefano La Rosa; Daniela Furlan; Francesca Franzi; Paolo Battaglia; Milo Frattini; Elena Zanellato; Alessandro Marando; Nora Sahnane; Mario Turri-Zanoni; Paolo Castelnuovo; Carlo Capella
Journal:  Head Neck Pathol       Date:  2012-06-28

10.  Colliding tumor of the paranasal sinus.

Authors:  Henry P Barham; Sherif Said; Vijay R Ramakrishnan
Journal:  Allergy Rhinol (Providence)       Date:  2013
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  2 in total

1.  Combined large cell neuroendocrine carcinoma and squamous cell carcinoma of the oropharynx: A collision course of tumors.

Authors:  Nicholas A Rossi; Rachelle Gietzen; Lauren T Malaya; Kareem B Haroun; Grant R Conner; Orly Coblens; Vicente A Resto; Cecilia G Clement; Rohan Joshi
Journal:  Clin Case Rep       Date:  2022-01-27

2.  Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports.

Authors:  Lun-Tao Woo; Yong-Feng Ding; Chen-Yu Mao; Jiong Qian; Xiu-Ming Zhang; Nong Xu
Journal:  World J Clin Cases       Date:  2022-08-06       Impact factor: 1.534
  2 in total

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