Anastase Dzudie1,2,3, Blaise Barche2, Sidick Mouliom1, Ariane Nouko2, Raissa Fogue2, Jules Ndjebet4, Serah Abang Makoh5, Joseph Abah6, Armel Djomou7, Archange Nzali2, Clovis Nkoke2, Felicite Kamdem1, Samuel Kingue3,8, Karen Sliwa9, Andre Pascal Kengne10,11. 1. Cardiology and Cardiac Pacing Unit, Douala General Hospital, Douala, Cameroon. 2. Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon. 3. Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon. 4. Douala Cardiovascular Center, Douala, Cameroon. 5. Mboppi Baptist Hospital, Douala, Cameroon. 6. Douala Military Hospital, Cameroon. 7. Clinique Cœur et vie, Douala, Cameroon. 8. Yaounde General Hospital, Cameroon. 9. Hatter Institute for Cardiovascular Research in Africa and the Institute of Infectious Disease and Molecular Medicine, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. 10. Department of Medicine, University of Cape Town, Cape Town, South Africa. 11. Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.
Abstract
BACKGROUND: Higher resting heart rate (HR) is associated with mortality amongst Caucasians with heart failure (HF), but its significance has yet to be established in sub-Saharan Africans in whom HF differs in terms of characteristics and etiologies. We assessed the association of HR with all-cause mortality in patients with HF in sub-Saharan Africa. METHODS: The Douala HF registry (Do-HF) is an ongoing prospective data collection on patients with HF receiving care at four cardiac referral services in Douala, Cameroon. Patients included in this report were followed-up for 12 months from their index admission, for all-cause mortality. We used Cox-regression analysis to study the association of HR with all-cause mortality during follow-up. RESULTS: Of 347 patients included, 343 (98.8%) completed follow-up. The mean age was 64±14 years, 176 (50.7%) were female, and median admission HR was 85 bpm. During a median follow-up of 12 months, 78 (22.7%) patients died. Mortality increased steadily with HR increase and ranged from 12.2% in the lower quartile of HR (≤69 bpm) to 34.1% in the upper quartile of HR (>100 bpm). Hazard ratio of 12-month death per 10 bpm higher HR was 1.16 (1.04-1.29), with consistent effects across most subgroups, but a higher effect in participants with hypertension vs. those without (interaction P=0.044). CONCLUSIONS: HR was independently associated with increased risk of all-cause mortality in this study, particularly among participants with hypertension. The implication of this finding for risk prediction or reduction should be actively investigated. 2021 Cardiovascular Diagnosis and Therapy. All rights reserved.
BACKGROUND: Higher resting heart rate (HR) is associated with mortality amongst Caucasians with heart failure (HF), but its significance has yet to be established in sub-Saharan Africans in whom HF differs in terms of characteristics and etiologies. We assessed the association of HR with all-cause mortality in patients with HF in sub-Saharan Africa. METHODS: The Douala HF registry (Do-HF) is an ongoing prospective data collection on patients with HF receiving care at four cardiac referral services in Douala, Cameroon. Patients included in this report were followed-up for 12 months from their index admission, for all-cause mortality. We used Cox-regression analysis to study the association of HR with all-cause mortality during follow-up. RESULTS: Of 347 patients included, 343 (98.8%) completed follow-up. The mean age was 64±14 years, 176 (50.7%) were female, and median admission HR was 85 bpm. During a median follow-up of 12 months, 78 (22.7%) patients died. Mortality increased steadily with HR increase and ranged from 12.2% in the lower quartile of HR (≤69 bpm) to 34.1% in the upper quartile of HR (>100 bpm). Hazard ratio of 12-month death per 10 bpm higher HR was 1.16 (1.04-1.29), with consistent effects across most subgroups, but a higher effect in participants with hypertension vs. those without (interaction P=0.044). CONCLUSIONS: HR was independently associated with increased risk of all-cause mortality in this study, particularly among participants with hypertension. The implication of this finding for risk prediction or reduction should be actively investigated. 2021 Cardiovascular Diagnosis and Therapy. All rights reserved.
Authors: D Aune; A Sen; B ó'Hartaigh; I Janszky; P R Romundstad; S Tonstad; L J Vatten Journal: Nutr Metab Cardiovasc Dis Date: 2017-04-21 Impact factor: 4.222
Authors: Valirie Ndip Agbor; Frank-Leonel Tianyi; Leopold Ndemnge Aminde; Clarence Mvalo Mbanga; Saint Just N Petnga; Larissa Pone Simo; Anastase Dzudie; Muchi Ditah Chobufo; Jean Jacques Noubiap Journal: BMJ Open Date: 2022-10-12 Impact factor: 3.006
Authors: Sophie Huhn; Ina Matzke; Mara Koch; Hanns-Christian Gunga; Martina Anna Maggioni; Ali Sié; Valentin Boudo; Windpanga Aristide Ouedraogo; Guillaume Compaoré; Aditi Bunker; Rainer Sauerborn; Till Bärnighausen; Sandra Barteit Journal: Front Public Health Date: 2022-09-30