Literature DB >> 33707831

Recent Advances in Molecular Diagnosis and Prognosis of Childhood B Cell Lineage Acute Lymphoblastic Leukemia (B-ALL).

Manisha Agarwal1, Rachna Seth2, Tathagata Chatterjee1.   

Abstract

B cell lineage acute lymphoblastic leukemia is the most common leukemia occurring in children and young adults and is the leading cause of cancer related deaths. The 5 year overall survival outcome in children with B-ALL has improved significantly in the last few decades. In the past, the discovery of various genetic alterations and targeted therapy have played a major role in decreasing disease-related deaths. In addition, numerous advances in the pathogenesis of B-ALL have been found which have provided better understanding of the genes involved in disease biology with respect to diagnostic and prognostic implications. Present review will summarize current understanding of risk stratification, genetic factors including cytogenetics in diagnosis and prognosis of B-ALL. © Indian Society of Hematology and Blood Transfusion 2020.

Entities:  

Keywords:  Targeted therapy; Copy number alterations; Cytogenetic risk groups

Year:  2020        PMID： 33707831      PMCID： PMC7900311          DOI： 10.1007/s12288-020-01295-8

Source DB:  PubMed          Journal:  Indian J Hematol Blood Transfus        ISSN： 0971-4502            Impact factor:   0.900


  82 in total

1.  The prognostic significance of CDKN2A, CDKN2B and MTAP inactivation in B-lineage acute lymphoblastic leukemia of childhood. Results of the EORTC studies 58881 and 58951.

Authors:  Delphine Mirebeau; Cécile Acquaviva; Stefan Suciu; Raphaëlle Bertin; Nicole Dastugue; Alain Robert; Patrick Boutard; Francoise Méchinaud; Emmanuel Plouvier; Jacques Otten; Etienne Vilmer; Hélène Cavé
Journal:  Haematologica       Date:  2006-07       Impact factor: 9.941

Review 2.  Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

Authors:  Peter L Bonate; Larry Arthaud; William R Cantrell; Katherine Stephenson; John A Secrist; Steve Weitman
Journal:  Nat Rev Drug Discov       Date:  2006-10       Impact factor: 84.694

3.  High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.

Authors:  Kathryn G Roberts; Zhaohui Gu; Debbie Payne-Turner; Kelly McCastlain; Richard C Harvey; I-Ming Chen; Deqing Pei; Ilaria Iacobucci; Marcus Valentine; Stanley B Pounds; Lei Shi; Yongjin Li; Jinghui Zhang; Cheng Cheng; Alessandro Rambaldi; Manuela Tosi; Orietta Spinelli; Jerald P Radich; Mark D Minden; Jacob M Rowe; Selina Luger; Mark R Litzow; Martin S Tallman; Peter H Wiernik; Ravi Bhatia; Ibrahim Aldoss; Jessica Kohlschmidt; Krzysztof Mrózek; Guido Marcucci; Clara D Bloomfield; Wendy Stock; Stephen Kornblau; Hagop M Kantarjian; Marina Konopleva; Elisabeth Paietta; Cheryl L Willman; Charles G Mullighan
Journal:  J Clin Oncol       Date:  2016-11-21       Impact factor: 44.544

4.  Allelic loss of selected tumor suppressor genes in acute lymphoblastic leukemia in children.

Authors:  E Studniak; E Maloney; T Ociepa; T Urasiński; K Skonieczka; O Haus; A Poluha; J Kowalczyk; S Zajączek
Journal:  Pol J Pathol       Date:  2013-06       Impact factor: 1.072

5.  Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial.

Authors:  Anthony V Moorman; Hannah M Ensor; Sue M Richards; Lucy Chilton; Claire Schwab; Sally E Kinsey; Ajay Vora; Chris D Mitchell; Christine J Harrison
Journal:  Lancet Oncol       Date:  2010-04-19       Impact factor: 41.316

Review 6.  Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma.

Authors:  Farhad Ravandi; Varsha Gandhi
Journal:  Expert Opin Investig Drugs       Date:  2006-12       Impact factor: 6.206

7.  Hyperdiploidy with 58-66 chromosomes in childhood B-acute lymphoblastic leukemia is highly curable: 58951 CLG-EORTC results.

Authors:  Nicole Dastugue; Stefan Suciu; Geneviève Plat; Frank Speleman; Hélène Cavé; Sandrine Girard; Marleen Bakkus; Marie Pierre Pagès; Karima Yakouben; Brigitte Nelken; Anne Uyttebroeck; Carine Gervais; Patrick Lutz; Manuel R Teixeira; Pierre Heimann; Alice Ferster; Pierre Rohrlich; Marie Agnès Collonge; Martine Munzer; Isabelle Luquet; Patrick Boutard; Nicolas Sirvent; Matthias Karrasch; Yves Bertrand; Yves Benoit
Journal:  Blood       Date:  2013-01-15       Impact factor: 22.113

8.  The location of breakpoints within the breakpoint cluster region (bcr) of chromosome 22 in chronic myeloid leukemia.

Authors:  A Eisenberg; R Silver; L Soper; Z Arlin; M Coleman; B Bernhardt; P Benn
Journal:  Leukemia       Date:  1988-10       Impact factor: 11.528

9.  Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP).

Authors:  Ilaria Iacobucci; Clelia Tiziana Storlazzi; Daniela Cilloni; Annalisa Lonetti; Emanuela Ottaviani; Simona Soverini; Annalisa Astolfi; Sabina Chiaretti; Antonella Vitale; Francesca Messa; Luciana Impera; Carmen Baldazzi; Pietro D'Addabbo; Cristina Papayannidis; Angelo Lonoce; Sabrina Colarossi; Marco Vignetti; Pier Paolo Piccaluga; Stefania Paolini; Domenico Russo; Fabrizio Pane; Giuseppe Saglio; Michele Baccarani; Robin Foà; Giovanni Martinelli
Journal:  Blood       Date:  2009-07-09       Impact factor: 22.113

Review 10.  Impact of blinatumomab on patient outcomes in relapsed/refractory acute lymphoblastic leukemia: evidence to date.

Authors:  Lindsey Hathaway; Jeremy Michael Sen; Michael Keng
Journal:  Patient Relat Outcome Meas       Date:  2018-10-02
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  1 in total

1.  Clinical features and prognosis of acute lymphoblastic leukemia in children with Epstein-Barr virus infection.

Authors:  Wei Deng; Yating Xu; Xunling Yuan
Journal:  Transl Pediatr       Date:  2022-05
  1 in total

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