| Literature DB >> 33707263 |
Umang Jain1, Aaron M Ver Heul1,2, Shanshan Xiong1, Martin H Gregory2, Elora G Demers3, Justin T Kern1, Chin-Wen Lai1,4, Brian D Muegge1,2,5, Derek A G Barisas1, J Steven Leal-Ekman1, Parakkal Deepak2, Matthew A Ciorba2, Ta-Chiang Liu1, Deborah A Hogan3, Philip Debbas6, Jonathan Braun6, Dermot P B McGovern6,7, David M Underhill6,7, Thaddeus S Stappenbeck8,9.
Abstract
Alterations of the mycobiota composition associated with Crohn's disease (CD) are challenging to link to defining elements of pathophysiology, such as poor injury repair. Using culture-dependent and -independent methods, we discovered that Debaryomyces hansenii preferentially localized to and was abundant within incompletely healed intestinal wounds of mice and inflamed mucosal tissues of CD human subjects. D. hansenii cultures from injured mice and inflamed CD tissues impaired colonic healing when introduced into injured conventionally raised or gnotobiotic mice. We reisolated D. hansenii from injured areas of these mice, fulfilling Koch's postulates. Mechanistically, D. hansenii impaired mucosal healing through the myeloid cell-specific type 1 interferon-CCL5 axis. Taken together, we have identified a fungus that inhabits inflamed CD tissue and can lead to dysregulated mucosal healing.Entities:
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Year: 2021 PMID： 33707263 DOI： 10.1126/science.abd0919
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714