Pavel Dundr1, Naveena Singh2,3, Barbora Nožičková4, Kristýna Němejcová4, Michaela Bártů4, Ivana Stružinská4. 1. Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studničkova 2, 128 00, Prague 2, Czech Republic. pavel.dundr@vfn.cz. 2. Department of Cellular Pathology, Barts Health NHS Trust, Queen Mary University of London, London, UK. 3. Blizard Institute of Core Pathology, Queen Mary University of London, London, UK. 4. Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studničkova 2, 128 00, Prague 2, Czech Republic.
Abstract
BACKGROUND: Making the distinction between primary mucinous and metastatic ovarian tumors is often difficult, especially in tumors with a primary source from the gastrointestinal tract, pancreas and biliary tree. The aim of the following paper is to provide an overview of the problematics, with a focus on the possibilities of the differential diagnosis at the macroscopic, microscopic and immunohistochemical level. MAIN BODY: The three main aspects of mucinous ovarian tumors are described in detail, including the comparison of the available diagnostic algorithms based on the evaluation of mostly macroscopic features, characterization of the spectrum of microscopic features, and a detailed analysis of the immunophenotype comparing 20 antibodies with the assessment of their statistical significance for differential diagnosis purposes. Specific features, including Krukenberg tumor and pseudomyxoma peritonei, are also discussed. CONCLUSION: Despite the growing knowledge of the macroscopic and microscopic features of ovarian mucinous tumors and the availability of a wide range of immunohistochemical antibodies useful in this setting, there still remains a group of tumors which cannot be precisely classified without close clinical-pathological cooperation.
BACKGROUND: Making the distinction between primary mucinous and metastatic ovarian tumors is often difficult, especially in tumors with a primary source from the gastrointestinal tract, pancreas and biliary tree. The aim of the following paper is to provide an overview of the problematics, with a focus on the possibilities of the differential diagnosis at the macroscopic, microscopic and immunohistochemical level. MAIN BODY: The three main aspects of mucinous ovarian tumors are described in detail, including the comparison of the available diagnostic algorithms based on the evaluation of mostly macroscopic features, characterization of the spectrum of microscopic features, and a detailed analysis of the immunophenotype comparing 20 antibodies with the assessment of their statistical significance for differential diagnosis purposes. Specific features, including Krukenberg tumor and pseudomyxoma peritonei, are also discussed. CONCLUSION: Despite the growing knowledge of the macroscopic and microscopic features of ovarian mucinous tumors and the availability of a wide range of immunohistochemical antibodies useful in this setting, there still remains a group of tumors which cannot be precisely classified without close clinical-pathological cooperation.
Authors: Pavel Dundr; Barbora Bazalová; Michaela Bártů; Tjalling Bosse; Jana Drozenová; Pavel Fabian; Oluwole Fadare; Jitka Hausnerová; Radek Jakša; Jan Laco; Sigurd F Lax; Radoslav Matěj; W Glenn McCluggage; Gábor Méhes; Romana Michálková; Kristýna Němejcová; Naveena Singh; Simona Stolnicu; Petr Škapa; Marián Švajdler; Ivana Stružinská Journal: Virchows Arch Date: 2022-05-13 Impact factor: 4.535
Authors: Stephen E Glombicki; Diego Montelongo; Swethen Dushianthan; Camilo J Perez; Mario Cervantes; Alan P Glombicki Journal: Cureus Date: 2022-04-29
Authors: Catherine M Tucker; Cheryl L Godcharles; Wei Jiang; Charles J Yeo; Norman G Rosenblum; Ethan J Halpern; William E Luginbuhl; Anthony J Prestipino Journal: J Pancreat Cancer Date: 2021-10-14