Literature DB >> 3370672

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family.

S Ohno1, Y Akita, Y Konno, S Imajoh, K Suzuki.   

Abstract

Protein kinase C (PKC)-related cDNA clones encode an 84 kd protein, nPKC. nPKC contains a cysteine-rich repeat sequence homologous to that seen in conventional PKCs (alpha, beta I, beta II, and gamma), which make up a family of 77-78 kd proteins with closely related sequences. nPKC, when expressed in COS cells, confers increased high-affinity phorbol ester receptor activity to intact cells. Antibodies raised against nPKC identified a 90 kd protein in rabbit brain extract as well as in extracts from COS cells transfected with the cDNA construct. nPKC shows protein kinase activity that is regulated by phospholipid, diacylglycerol, and phorbol ester but is independent of Ca2+. The structural and enzymological characteristics of nPKC clearly distinguish it from conventional PKCs, which until now have been the only substances believed to mediate the various effects of diacylglycerol and phorbol esters. These results suggest an additional signaling pathway involving nPKC.

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Year:  1988        PMID： 3370672     DOI： 10.1016/0092-8674(88)90091-8

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  75 in total

1.  Activation of the epsilon isoform of protein kinase C in the mammalian nerve terminal.

Authors:  N Saitoh; T Hori; T Takahashi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

Review 2.  Activation and regulation of protein kinase C enzymes.

Authors:  G L Nelsestuen; M D Bazzi
Journal:  J Bioenerg Biomembr       Date:  1991-02       Impact factor: 2.945

3.  A novel Bacillus subtilis gene involved in negative control of sporulation and degradative-enzyme production.

Authors:  M Honjo; A Nakayama; K Fukazawa; K Kawamura; K Ando; M Hori; Y Furutani
Journal:  J Bacteriol       Date:  1990-04       Impact factor: 3.490

4.  A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.

Authors:  I N Maruyama; S Brenner
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

5.  The regulatory domain of protein kinase C-epsilon restricts the catalytic-domain-specificity.

Authors:  C Pears; D Schaap; P J Parker
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

6.  Protein kinase C isoforms in pituitary cells displaying differential sensitivity to phorbol ester.

Authors:  D J MacEwan; M S Johnson; R Mitchell
Journal:  Mol Cell Biochem       Date:  1999-12       Impact factor: 3.396

7.  A relative of the catalytic subunit of cyclic AMP-dependent protein kinase in Aplysia spermatozoa.

Authors:  S Beushausen; H Bayley
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

8.  Ca(2+)-independent form of protein kinase C may regulate Na+ transport across frog skin.

Authors:  M M Civan; A Oler; K Peterson-Yantorno; K George; T G O'Brien
Journal:  J Membr Biol       Date:  1991-04       Impact factor: 1.843

9.  The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus.

Authors:  H Greif; J Ben-Chaim; T Shimon; E Bechor; H Eldar; E Livneh
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

10.  Isolation and characterization of delta-subspecies of protein kinase C from rat brain.

Authors:  K Ogita; S Miyamoto; K Yamaguchi; H Koide; N Fujisawa; U Kikkawa; S Sahara; Y Fukami; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205
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