Yong-Jie Yan1,2,3, Jia Huang1,4, Simon S Y Lui5,6, Eric F C Cheung5, Kristoffer H Madsen2,3,7,8, Raymond C K Chan1,2,3,4. 1. Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China. 2. Sino-Danish College of University of Chinese Academy of Sciences, Beijing, People's Republic of China. 3. Sino-Danish Centre for Education and Research, Beijing, People's Republic of China. 4. Department of Psychology, the University of Chinese Academy of Sciences, Beijing, People's Republic of China. 5. Castle Peak Hospital, Hong Kong, People's Republic of China. 6. Department of Psychiatry, University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China. 7. Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. 8. Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark.
Abstract
INTRODUCTION: Effort-reward imbalance (ERI) is a typical psychosocial stress. Schizotypal traits are attenuated features of schizophrenia in the general population. According to the diathesis-stress model, schizotypal traits and psychosocial stress contribute to the onset of schizophrenia. However, few studies examined the effects of these factors on brain alterations. This study aimed to examine relationships between ERI, schizotypal traits and brain structures and functions. METHODS: We recruited 37 (13 male, 24 female) participants with high levels of schizotypal traits and 36 (12 male, 24 female) participants with low levels of schizotypal traits by the Schizotypal Personality Questionnaire (SPQ). The Chinese school version of the effort-reward imbalance questionnaire (C-ERI-S) was used to measure ERI. We conducted the voxel-based morphometry (VBM) and whole brain resting-state functional connectivity (rsFC) analysis using reward or stress-related regions as seeds. RESULTS: Participants with high levels of schizotypal traits were more likely to perceive ERI. The severity of ERI was correlated with grey matter volume (GMV) reduction of the left pallidum and altered rsFC among the prefrontal, striatum and cerebellum in participants with high levels of schizotypal traits. CONCLUSION: ERI is associated with GMV reduction and altered rsFC in individuals with high levels of schizotypal traits.
INTRODUCTION: Effort-reward imbalance (ERI) is a typical psychosocial stress. Schizotypal traits are attenuated features of schizophrenia in the general population. According to the diathesis-stress model, schizotypal traits and psychosocial stress contribute to the onset of schizophrenia. However, few studies examined the effects of these factors on brain alterations. This study aimed to examine relationships between ERI, schizotypal traits and brain structures and functions. METHODS: We recruited 37 (13 male, 24 female) participants with high levels of schizotypal traits and 36 (12 male, 24 female) participants with low levels of schizotypal traits by the Schizotypal Personality Questionnaire (SPQ). The Chinese school version of the effort-reward imbalance questionnaire (C-ERI-S) was used to measure ERI. We conducted the voxel-based morphometry (VBM) and whole brain resting-state functional connectivity (rsFC) analysis using reward or stress-related regions as seeds. RESULTS:Participants with high levels of schizotypal traits were more likely to perceive ERI. The severity of ERI was correlated with grey matter volume (GMV) reduction of the left pallidum and altered rsFC among the prefrontal, striatum and cerebellum in participants with high levels of schizotypal traits. CONCLUSION: ERI is associated with GMV reduction and altered rsFC in individuals with high levels of schizotypal traits.
Authors: Yong-Jie Yan; Hui-Xin Hu; Ling-Ling Wang; Yi-Jing Zhang; Simon S Y Lui; Jia Huang; Raymond C K Chan Journal: Eur Arch Psychiatry Clin Neurosci Date: 2022-05-31 Impact factor: 5.270
Authors: América Vera-Montecinos; Ricard Rodríguez-Mias; Karina S MacDowell; Borja García-Bueno; Álvaro G Bris; Javier R Caso; Judit Villén; Belén Ramos Journal: Int J Mol Sci Date: 2021-09-17 Impact factor: 5.923