Andrew W Manigault1, Kate R Kuhlman2, Michael R Irwin3, Steve W Cole4, Patricia A Ganz5, Catherine M Crespi6, Julienne E Bower7. 1. Department of Psychology, UCLA, Los Angeles, CA, United States. Electronic address: amanigault@psych.ucla.edu. 2. Department of Psychological Science, UCI, Irvine, CA, United States; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, United States. 3. Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, United States. 4. Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, United States; David Geffen School of Medicine, UCLA, Los Angeles, CA, United States. 5. David Geffen School of Medicine, UCLA, Los Angeles, CA, United States; Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, United States. 6. Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, United States. 7. Department of Psychology, UCLA, Los Angeles, CA, United States; Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, United States.
Abstract
BACKGROUND: Stress precipitates depression and may do so in part by increasing susceptibility to inflammation-induced depressive symptoms. However, this has not been examined among individuals facing a major life stressor. Accordingly, the present study tested the moderating role of stress on the longitudinal association between inflammation and depressive symptoms among women with breast cancer. METHODS: Women recently diagnosed with early-stage breast cancer (N = 187) were enrolled before starting adjuvant/neoadjuvant treatment. Blood draws and self-reported depressive symptoms were collected pre-treatment, post-treatment, and at 6, 12, and 18-month post-treatment follow ups. C-reactive protein (CRP) was used to index inflammation. Measures of psychological stress, including cancer-related stress, general stress perceptions, and childhood stress, were administered pre-treatment. RESULTS: Stress moderated the association between CRP and depressive symptoms, such that higher levels of CRP were associated with elevated depressive symptoms only among women who reported high cancer-related stress (β = 0.080, p = .002) and perceived stress (β = 0.053, p = .044); childhood stress effects were non-significant. Moreover, elevated CRP was associated with increased odds of exhibiting clinically significant depressive symptoms (OR = 1.64, p < .001) among women who reported high cancer-related stress. Results were independent of age, BMI, race and cancer-related covariates. CONCLUSIONS: Stress was found to heighten sensitivity to inflammation-associated depressive symptoms over a 2-year period, with notably stronger effects for subjective stress responses to a concurrent life event. Individuals who are most distressed following a major life event may exhibit the greatest risk for inflammation-induced depression.
BACKGROUND: Stress precipitates depression and may do so in part by increasing susceptibility to inflammation-induced depressive symptoms. However, this has not been examined among individuals facing a major life stressor. Accordingly, the present study tested the moderating role of stress on the longitudinal association between inflammation and depressive symptoms among women with breast cancer. METHODS: Women recently diagnosed with early-stage breast cancer (N = 187) were enrolled before starting adjuvant/neoadjuvant treatment. Blood draws and self-reported depressive symptoms were collected pre-treatment, post-treatment, and at 6, 12, and 18-month post-treatment follow ups. C-reactive protein (CRP) was used to index inflammation. Measures of psychological stress, including cancer-related stress, general stress perceptions, and childhood stress, were administered pre-treatment. RESULTS: Stress moderated the association between CRP and depressive symptoms, such that higher levels of CRP were associated with elevated depressive symptoms only among women who reported high cancer-related stress (β = 0.080, p = .002) and perceived stress (β = 0.053, p = .044); childhood stress effects were non-significant. Moreover, elevated CRP was associated with increased odds of exhibiting clinically significant depressive symptoms (OR = 1.64, p < .001) among women who reported high cancer-related stress. Results were independent of age, BMI, race and cancer-related covariates. CONCLUSIONS: Stress was found to heighten sensitivity to inflammation-associated depressive symptoms over a 2-year period, with notably stronger effects for subjective stress responses to a concurrent life event. Individuals who are most distressed following a major life event may exhibit the greatest risk for inflammation-induced depression.
Authors: David Goldstein; Barbara K Bennett; Kate Webber; Fran Boyle; Paul L de Souza; Nicholas R C Wilcken; Elizabeth M Scott; Ruth Toppler; Penelope Murie; Linda O'Malley; Junie McCourt; Michael Friedlander; Ian B Hickie; Andrew R Lloyd Journal: J Clin Oncol Date: 2012-04-16 Impact factor: 44.544
Authors: Caroline Menard; Madeline L Pfau; Georgia E Hodes; Veronika Kana; Victoria X Wang; Sylvain Bouchard; Aki Takahashi; Meghan E Flanigan; Hossein Aleyasin; Katherine B LeClair; William G Janssen; Benoit Labonté; Eric M Parise; Zachary S Lorsch; Sam A Golden; Mitra Heshmati; Carol Tamminga; Gustavo Turecki; Matthew Campbell; Zahi A Fayad; Cheuk Ying Tang; Miriam Merad; Scott J Russo Journal: Nat Neurosci Date: 2017-11-13 Impact factor: 24.884
Authors: Andrew W Manigault; Kate R Kuhlman; Michael R Irwin; Steve W Cole; Patricia A Ganz; Catherine M Crespi; Julienne E Bower Journal: Psychol Sci Date: 2022-08-05
Authors: Andrew W Manigault; Patricia A Ganz; Michael R Irwin; Steve W Cole; Kate R Kuhlman; Julienne E Bower Journal: Transl Psychiatry Date: 2021-12-06 Impact factor: 6.222