Literature DB >> 33705703

Methotrexate works remotely, from the gut.

Hsin-Jung Joyce Wu1.   

Abstract

In this COVID era, when many struggle to work remotely, methotrexate (MTX) has been doing so all along. In this issue of Cell Host & Microbe, Nayak et al. discover that MTX reduces immune activation due to off-target effects on the gut microbiota, potentially explaining MTX's anti-inflammatory effects.
Copyright © 2021 Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 33705703     DOI： 10.1016/j.chom.2021.02.016

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   31.316


  3 in total

1.  Oral and Intestinal Bacterial Substances Associated with Disease Activities in Patients with Rheumatoid Arthritis: A Cross-Sectional Clinical Study.

Authors:  Kaori Kitamura; Hiroshi Shionoya; Suguru Suzuki; Richio Fukai; Shinichi Uda; Chiyuki Abe; Hiromitsu Takemori; Keita Nishimura; Hisashi Baba; Kou Katayama; Kuniaki Terato; Takaki Waritani
Journal:  J Immunol Res       Date:  2022-02-18       Impact factor: 4.818

Review 2.  Another Look at the Contribution of Oral Microbiota to the Pathogenesis of Rheumatoid Arthritis: A Narrative Review.

Authors:  Jean-Marie Berthelot; Octave Nadile Bandiaky; Benoit Le Goff; Gilles Amador; Anne-Gaelle Chaux; Assem Soueidan; Frederic Denis
Journal:  Microorganisms       Date:  2021-12-28

3.  Metabolomic Profiling Identifies Exogenous and Microbiota-Derived Metabolites as Markers of Methotrexate Efficacy in Juvenile Idiopathic Arthritis.

Authors:  Ryan Sol Funk; Mara L Becker
Journal:  Front Pharmacol       Date:  2021-12-09       Impact factor: 5.810
  3 in total

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