Alwyn Gomez1,2, Carleen Batson2, Logan Froese3, Frederick A Zeiler4,5,6,7,8. 1. Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. 2. Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. 3. Biomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB, Canada. 4. Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. Frederick.Zeiler@umanitoba.ca. 5. Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. Frederick.Zeiler@umanitoba.ca. 6. Biomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB, Canada. Frederick.Zeiler@umanitoba.ca. 7. Centre on Aging, University of Manitoba, Winnipeg, MB, Canada. Frederick.Zeiler@umanitoba.ca. 8. Division of Anaesthesia, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. Frederick.Zeiler@umanitoba.ca.
Abstract
PURPOSE OF REVIEW: Traumatic brain injury (TBI) has a significant burden of disease worldwide and outcomes vary widely. Current prognostic tools fail to fully account for this variability despite incorporating clinical, radiographic, and biochemical data. This variance could possibly be explained by genotypic differences in the patient population. In this review, we explore single nucleotide polymorphism (SNP) TBI outcome association studies. RECENT FINDINGS: In recent years, SNP association studies in TBI have focused on global, neurocognitive/neuropsychiatric, and physiologic outcomes. While the APOE gene has been the most extensively studied, other genes associated with neural repair, cell death, the blood-brain barrier, cerebral edema, neurotransmitters, mitochondria, and inflammatory cytokines have all been examined for their association with various outcomes following TBI. The results have been mixed across studies and even within genes. SNP association studies provide insight into mechanisms by which outcomes may vary following TBI. Their individual clinical utility, however, is often limited by small sample sizes and poor reproducibility. In the future, they may serve as hypothesis generating for future therapeutic targets.
PURPOSE OF REVIEW: Traumatic brain injury (TBI) has a significant burden of disease worldwide and outcomes vary widely. Current prognostic tools fail to fully account for this variability despite incorporating clinical, radiographic, and biochemical data. This variance could possibly be explained by genotypic differences in the patient population. In this review, we explore single nucleotide polymorphism (SNP) TBI outcome association studies. RECENT FINDINGS: In recent years, SNP association studies in TBI have focused on global, neurocognitive/neuropsychiatric, and physiologic outcomes. While the APOE gene has been the most extensively studied, other genes associated with neural repair, cell death, the blood-brain barrier, cerebral edema, neurotransmitters, mitochondria, and inflammatory cytokines have all been examined for their association with various outcomes following TBI. The results have been mixed across studies and even within genes. SNP association studies provide insight into mechanisms by which outcomes may vary following TBI. Their individual clinical utility, however, is often limited by small sample sizes and poor reproducibility. In the future, they may serve as hypothesis generating for future therapeutic targets.
Authors: Michelle D Failla; Raj G Kumar; Andrew B Peitzman; Yvette P Conley; Robert E Ferrell; Amy K Wagner Journal: Neurorehabil Neural Repair Date: 2014-07-24 Impact factor: 3.919
Authors: Hester F Lingsma; John K Yue; Andrew I R Maas; Ewout W Steyerberg; Geoffrey T Manley Journal: J Neurotrauma Date: 2014-11-25 Impact factor: 5.269
Authors: Bob Roozenbeek; Hester F Lingsma; Fiona E Lecky; Juan Lu; James Weir; Isabella Butcher; Gillian S McHugh; Gordon D Murray; Pablo Perel; Andrew I Maas; Ewout W Steyerberg Journal: Crit Care Med Date: 2012-05 Impact factor: 7.598