| Literature DB >> 33693750 |
Guoxin Wu1, Paul Zuck1, Shih Lin Goh1, Jeffrey M Milush2, Poonam Vohra3, Joseph K Wong4, Ma Somsouk5, Steven A Yukl4, Barbara L Shacklett6, Nicolas Chomont7, Ashley T Haase8, Hiroyu Hatano9, Timothy W Schacker10, Steven G Deeks9, Daria J Hazuda1, Peter W Hunt2, Bonnie J Howell1.
Abstract
We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4+ T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8+ T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.Entities:
Keywords: HIV; HIV persistence; biomarker; fine needle aspirates; gag p24; lymph nodes; rectal biopsy
Mesh：
Substances：
Year: 2021 PMID： 33693750 PMCID： PMC8599810 DOI： 10.1093/infdis/jiab121
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226