Literature DB >> 33693749

Sex differences in the evolution of neutralizing antibodies to SARS-CoV-2.

Ludivine Grzelak1,2, Aurélie Velay3,4, Yoann Madec5, Floriane Gallais3,4, Isabelle Staropoli1, Catherine Schmidt-Mutter6, Marie-Josée Wendling3,4, Nicolas Meyer7, Cyril Planchais8, David Rey9, Hugo Mouquet8, Nathalie Reix10, Ludovic Glady10, Yves Hansmann11, Timothée Bruel1, Jérome De Séze6,12, Arnaud Fontanet5, Maria Gonzalez13, Olivier Schwartz1,14, Samira Fafi-Kremer3,4.   

Abstract

We measured Anti-Spike (S), Nucleoprotein (N) and neutralizing antibodies (NAbs) in sera from 308 RT-qPCR + healthcare workers with mild disease, collected at two time-points up to 6 months after symptom onset. At Month 1 (M1), anti-S and N antibody levels were higher in males > 50 years or with a body mass index (BMI) > 25. At M3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and NAbs declined faster in males than in females, independently of age and BMI, suggesting an association of sex with evolution of the humoral response.
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  COVID-19; SARS-CoV-2; antibodies; sex-related differences

Year:  2021        PMID： 33693749      PMCID： PMC7989436          DOI： 10.1093/infdis/jiab127

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  22 in total

1.  Prevalence of Anti-SARS-CoV-2 Antibodies and Potential Determinants among the Belgian Adult Population: Baseline Results of a Prospective Cohort Study.

Authors:  Victoria Leclercq; Nayema Van den Houte; Lydia Gisle; Inge Roukaerts; Cyril Barbezange; Isabelle Desombere; Els Duysburgh; Johan Van der Heyden
Journal:  Viruses       Date:  2022-04-28       Impact factor: 5.818

2.  Durability of SARS-CoV-2 Specific IgG Antibody Responses Following Two Doses of Match and Mixed COVID-19 Vaccines Regimens in Saudi Population.

Authors:  Ayman Mubarak; Saeedah Almutairi; Abulrahman D Al-Dhabbah; Shaha Y Aldabas; Rauf Bhat; Mahfoudh M Alqoufail; Mostafa A Abdel-Maksoud; Taghreed N Almanaa; Mohamed A Farrag; Wael Alturaiki
Journal:  Infect Drug Resist       Date:  2022-07-15       Impact factor: 4.177

3.  SARS-CoV-2 antibody kinetics eight months from COVID-19 onset: Persistence of spike antibodies but loss of neutralizing antibodies in 24% of convalescent plasma donors.

Authors:  Evangelos Terpos; Dimitris Stellas; Margherita Rosati; Theodoros N Sergentanis; Xintao Hu; Marianna Politou; Vassiliki Pappa; Ioannis Ntanasis-Stathopoulos; Sevasti Karaliota; Jenifer Bear; Duncan Donohue; Maria Pagoni; Elisavet Grouzi; Eleni Korompoki; George N Pavlakis; Barbara K Felber; Meletios A Dimopoulos
Journal:  Eur J Intern Med       Date:  2021-05-18       Impact factor: 7.749

4.  Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals.

Authors:  Alena J Markmann; Natasa Giallourou; D Ryan Bhowmik; Yixuan J Hou; Aaron Lerner; David R Martinez; Lakshmanane Premkumar; Heather Root; David van Duin; Sonia Napravnik; Stephen D Graham; Quique Guerra; Rajendra Raut; Christos J Petropoulos; Terri Wrin; Caleb Cornaby; John Schmitz; JoAnn Kuruc; Susan Weiss; Yara Park; Ralph Baric; Aravinda M de Silva; David M Margolis; Luther A Bartelt
Journal:  mSphere       Date:  2021-08-25       Impact factor: 4.389

5.  Influenza vaccination reveals and partly reverses sex dimorphic immune imprints associated with prior mild COVID-19.

Authors:  Rachel Sparks; William W Lau; Can Liu; Kyu Lee Han; Kiera L Vrindten; Guangping Sun; Milann Cox; Sarah F Andrews; Neha Bansal; Laura E Failla; Jody Manischewitz; Gabrielle Grubbs; Lisa R King; Galina Koroleva; Stephanie Leimenstoll; LaQuita Snow; Jinguo Chen; Juanjie Tang; Amrita Mukherjee; Brian A Sellers; Richard Apps; Adrian B McDermott; Andrew J Martins; Evan M Bloch; Hana Golding; Surender Khurana; John S Tsang
Journal:  medRxiv       Date:  2022-02-22

Review 6.  Sex Differences in Immunity to Viral Infections.

Authors:  Henning Jacobsen; Sabra L Klein
Journal:  Front Immunol       Date:  2021-08-31       Impact factor: 7.561

7.  Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2.

Authors:  Jean-Louis Bayart; Laure Morimont; Mélanie Closset; Grégoire Wieërs; Tatiana Roy; Vincent Gerin; Marc Elsen; Christine Eucher; Sandrine Van Eeckhoudt; Nathalie Ausselet; Clara David; François Mullier; Jean-Michel Dogné; Julien Favresse; Jonathan Douxfils
Journal:  Microorganisms       Date:  2021-06-21

8.  Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom.

Authors:  Koen B Pouwels; David W Eyre; A Sarah Walker; Jia Wei; Nicole Stoesser; Philippa C Matthews; Daniel Ayoubkhani; Ruth Studley; Iain Bell; John I Bell; John N Newton; Jeremy Farrar; Ian Diamond; Emma Rourke; Alison Howarth; Brian D Marsden; Sarah Hoosdally; E Yvonne Jones; David I Stuart; Derrick W Crook; Tim E A Peto
Journal:  Nat Microbiol       Date:  2021-07-21       Impact factor: 17.745

9.  Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus.

Authors:  Ioannis Mamais; Apostolos Malatras; Gregory Papagregoriou; Natasa Giallourou; Andrea C Kakouri; Peter Karayiannis; Maria Koliou; Eirini Christaki; Georgios K Nikolopoulos; Constantinos Deltas
Journal:  J Clin Med       Date:  2021-12-15       Impact factor: 4.241

10.  Persistence of anti-SARS-CoV-2 antibodies: immunoassay heterogeneity and implications for serosurveillance.

Authors:  Javier Perez-Saez; María-Eugenia Zaballa; Sabine Yerly; Diego O Andrey; Benjamin Meyer; Isabella Eckerle; Jean-François Balavoine; François Chappuis; Didier Pittet; Didier Trono; Omar Kherad; Nicolas Vuilleumier; Laurent Kaiser; Idris Guessous; Silvia Stringhini; Andrew S Azman
Journal:  Clin Microbiol Infect       Date:  2021-07-07       Impact factor: 8.067
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