Caro Minschart1, Kyara De Weerdt2, Astrid Elegeert2, Paul Van Crombrugge3, Carolien Moyson1, Johan Verhaeghe4, Sofie Vandeginste5, Hilde Verlaenen5, Chris Vercammen6, Toon Maes6, Els Dufraimont7, Christophe De Block8, Yves Jacquemyn9, Farah Mekahli10, Katrien De Clippel11, Annick Van Den Bruel12, Anne Loccufier13, Annouschka Laenen14, Roland Devlieger4, Chantal Mathieu1, Katrien Benhalima1. 1. Department of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium. 2. Medicine, KU Leuven, Leuven, Belgium. 3. Department of Endocrinology, OLV ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium. 4. Department of Obstetrics and Gynecology, UZ Gasthuisberg, KU Leuven, Leuven, Belgium. 5. Department of Obstetrics and Gynecology, OLV ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium. 6. Department of Endocrinology, Imelda ziekenhuis, Bonheiden, Belgium. 7. Department of Obstetrics and Gynecology, Imelda ziekenhuis, Bonheiden, Belgium. 8. Department of Endocrinology-Diabetology-Metabolism, Antwerp University Hospital, Edegem, Belgium. 9. Department of Obstetrics and Gynecology, Antwerp University Hospital, Edegem, Belgium. 10. Department of Endocrinology, Kliniek St-Jan Brussel, Brussel, Belgium. 11. Department of Obstetrics and Gynecology, Kliniek St-Jan Brussel, Brussel, Belgium. 12. Department of Endocrinology, AZ St Jan Brugge, Brugge, Belgium. 13. Department of Obstetrics and Gynecology, AZ St Jan Brugge, Brugge, Belgium. 14. Center of Biostatics and Statistical bioinformatics, KU Leuven, 3000 Leuven, Belgium.
Abstract
AIMS: To determine the impact of depressive symptoms on pregnancy outcomes and postpartum quality of life in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT). METHODS: 1843 women from a prospective cohort study received universal GDM screening with an oral glucose tolerance test (OGTT). The Center for Epidemiologic Studies-Depression questionnaire was completed before GDM diagnosis was communicated and in GDM women in early postpartum. All participants completed the 36-Item Short Form Health Survey (SF-36) health survey postpartum. RESULTS: Women who developed GDM (231; 12.5%) had significantly more often depressive symptoms than NGT (1612; 87.5%) women [21.3% (48) vs 15.1% (239), odds ratio (OR) 1.52, 95% confidence interval (CI) (1.08-2.16), P = 0.017]. Compared to GDM women without depressive symptoms, depressed GDM women attended less often the postpartum OGTT [68.7% (33) vs 87.6% (155), P = 0.002], remained more often depressed [37.1% (13) vs 12.4% (19), P < 0.001], and had lower SF-36 scores postpartum. There were no significant differences in pregnancy outcomes between both groups. Rates of labor inductions were significantly higher in the NGT group with depressive symptoms compared to the nondepressed NGT group [31.7% (75) vs 24.7% (330), adjusted OR (aOR) 1.40, 95% CI (1.01-1.93), P = 0.041]. NGT women with depressive symptoms had lower SF-36 scores (P < 0.001) postpartum compared to nondepressed NGT women. CONCLUSIONS: Women with antenatal symptoms of depression develop more often GDM. GDM women with depressive symptoms remain more often depressed postpartum with lower quality of life. NGT women with depressive symptoms have higher rates of labor inductions and lower quality of life postpartum compared to nondepressed NGT women.
AIMS: To determine the impact of depressive symptoms on pregnancy outcomes and postpartum quality of life in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT). METHODS: 1843 women from a prospective cohort study received universal GDM screening with an oral glucose tolerance test (OGTT). The Center for Epidemiologic Studies-Depression questionnaire was completed before GDM diagnosis was communicated and in GDM women in early postpartum. All participants completed the 36-Item Short Form Health Survey (SF-36) health survey postpartum. RESULTS:Women who developed GDM (231; 12.5%) had significantly more often depressive symptoms than NGT (1612; 87.5%) women [21.3% (48) vs 15.1% (239), odds ratio (OR) 1.52, 95% confidence interval (CI) (1.08-2.16), P = 0.017]. Compared to GDM women without depressive symptoms, depressed GDM women attended less often the postpartum OGTT [68.7% (33) vs 87.6% (155), P = 0.002], remained more often depressed [37.1% (13) vs 12.4% (19), P < 0.001], and had lower SF-36 scores postpartum. There were no significant differences in pregnancy outcomes between both groups. Rates of labor inductions were significantly higher in the NGT group with depressive symptoms compared to the nondepressed NGT group [31.7% (75) vs 24.7% (330), adjusted OR (aOR) 1.40, 95% CI (1.01-1.93), P = 0.041]. NGT women with depressive symptoms had lower SF-36 scores (P < 0.001) postpartum compared to nondepressed NGT women. CONCLUSIONS:Women with antenatal symptoms of depression develop more often GDM. GDM women with depressive symptoms remain more often depressed postpartum with lower quality of life. NGT women with depressive symptoms have higher rates of labor inductions and lower quality of life postpartum compared to nondepressed NGT women.
Authors: Louise Fritsche; Julia Hummel; Robert Wagner; Dorina Löffler; Julia Hartkopf; Jürgen Machann; Johannes Hilberath; Konstantinos Kantartzis; Peter Jakubowski; Jan Pauluschke-Fröhlich; Sara Brucker; Sebastian Hörber; Hans-Ulrich Häring; Michael Roden; Annette Schürmann; Michele Solimena; Martin Hrabe de Angelis; Andreas Peter; Andreas L Birkenfeld; Hubert Preissl; Andreas Fritsche; Martin Heni Journal: BMJ Open Date: 2022-02-15 Impact factor: 2.692
Authors: Lore Raets; Marie Vandewinkel; Paul Van Crombrugge; Carolien Moyson; Johan Verhaeghe; Sofie Vandeginste; Hilde Verlaenen; Chris Vercammen; Toon Maes; Els Dufraimont; Nele Roggen; Christophe De Block; Yves Jacquemyn; Farah Mekahli; Katrien De Clippel; Annick Van Den Bruel; Anne Loccufier; Annouschka Laenen; Roland Devlieger; Chantal Mathieu; Katrien Benhalima Journal: Front Endocrinol (Lausanne) Date: 2021-11-08 Impact factor: 5.555