Katherine C Wu1, Sabina A Haberlen2, Michael W Plankey3, Frank J Palella4, Damani A Piggott2,5, Gregory D Kirk2,5, Joseph B Margolick6, Wendy S Post1,2. 1. Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 559, 600 North Wolfe Street, Baltimore, MD 21287, USA. 2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 3. Department of Medicine, Georgetown University Medical Center, Washington, DC, USA. 4. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 5. Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Abstract
AIMS: The extent to which human immunodeficiency viral (HIV) infection is independently associated with myocardial disease in the era of combination antiretroviral therapy (cART) remains understudied. We assessed differences in cardiovascular magnetic resonance imaging (CMR) metrics among people living with HIV (PLWH) and without HIV (PWOH). METHODS AND RESULTS: Among 436 participants (aged 54.7 ± 6.0 years, 29% women) from three cohorts, we acquired CMR cines, late gadolinium enhancement (LGE), and T1 mapping. Multivariable linear regressions were used to evaluate associations between HIV serostatus and CMR metrics. Baseline characteristics were similar by HIV serostatus; 63% were PLWH of whom 88% received cART and 73% were virally suppressed. Median left ventricular ejection fraction was normal and similar by HIV serostatus (73%, PWOH vs. 72%, PLWH, P = 0.43) as were right ventricular function, biventricular volumes, and masses. LGE prevalence was similar (32%, PWOH vs. 36%, PLWH, P = 0.46) with low scar extents (4.1, PWOH vs. 4.9 g, PLWH, P = 0.51) and few ischaemic scars (3%, PWOH vs. 4%, PLWH, P = 0.70). Extracellular volume fraction (ECV) was higher among PLWH (29.2 ± 4.1% vs. 28.3 ± 3.7%, P = 0.04) as was indexed maximum left atrial (LA) volume (LAVI, 29.7 ± 10.3 vs. 27.8 ± 8.7 mL/m2, P = 0.05). After multivariate adjustment, ECV was 0.84% higher among PLWH (P = 0.05) and LAVI was 2.45 mL/m2 larger (P = 0.01). HIV seropositivity and higher ECV contributed to higher LAVI (P < 0.02). There were no associations between HIV disease severity and CMR metrics among PLWH. CONCLUSION: HIV seropositivity was independently associated with greater diffuse non-ischaemic fibrosis and larger LA volume but no other differences in CMR metrics. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The extent to which human immunodeficiency viral (HIV) infection is independently associated with myocardial disease in the era of combination antiretroviral therapy (cART) remains understudied. We assessed differences in cardiovascular magnetic resonance imaging (CMR) metrics among people living with HIV (PLWH) and without HIV (PWOH). METHODS AND RESULTS: Among 436 participants (aged 54.7 ± 6.0 years, 29% women) from three cohorts, we acquired CMR cines, late gadolinium enhancement (LGE), and T1 mapping. Multivariable linear regressions were used to evaluate associations between HIV serostatus and CMR metrics. Baseline characteristics were similar by HIV serostatus; 63% were PLWH of whom 88% received cART and 73% were virally suppressed. Median left ventricular ejection fraction was normal and similar by HIV serostatus (73%, PWOH vs. 72%, PLWH, P = 0.43) as were right ventricular function, biventricular volumes, and masses. LGE prevalence was similar (32%, PWOH vs. 36%, PLWH, P = 0.46) with low scar extents (4.1, PWOH vs. 4.9 g, PLWH, P = 0.51) and few ischaemic scars (3%, PWOH vs. 4%, PLWH, P = 0.70). Extracellular volume fraction (ECV) was higher among PLWH (29.2 ± 4.1% vs. 28.3 ± 3.7%, P = 0.04) as was indexed maximum left atrial (LA) volume (LAVI, 29.7 ± 10.3 vs. 27.8 ± 8.7 mL/m2, P = 0.05). After multivariate adjustment, ECV was 0.84% higher among PLWH (P = 0.05) and LAVI was 2.45 mL/m2 larger (P = 0.01). HIV seropositivity and higher ECV contributed to higher LAVI (P < 0.02). There were no associations between HIV disease severity and CMR metrics among PLWH. CONCLUSION: HIV seropositivity was independently associated with greater diffuse non-ischaemic fibrosis and larger LA volume but no other differences in CMR metrics. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Raza M Alvi; Anne M Neilan; Noor Tariq; Malek O Hassan; Magid Awadalla; Lili Zhang; Maryam Afshar; Adam Rokicki; Connor P Mulligan; Virginia A Triant; Markella V Zanni; Tomas G Neilan Journal: JACC Heart Fail Date: 2019-08-07 Impact factor: 12.035
Authors: S E Barkan; S L Melnick; S Preston-Martin; K Weber; L A Kalish; P Miotti; M Young; R Greenblatt; H Sacks; J Feldman Journal: Epidemiology Date: 1998-03 Impact factor: 4.822
Authors: Julian A Luetkens; Jonas Doerner; Carolynne Schwarze-Zander; Jan-Christian Wasmuth; Christoph Boesecke; Alois M Sprinkart; Frederic C Schmeel; Rami Homsi; Juergen Gieseke; Hans H Schild; Jürgen K Rockstroh; Claas P Naehle Journal: Circ Cardiovasc Imaging Date: 2016-03 Impact factor: 7.792
Authors: Sujata M Shanbhag; Anders M Greve; Thor Aspelund; Erik B Schelbert; J Jane Cao; Ragnar Danielsen; Guðmundur Þorgeirsson; Sigurður Sigurðsson; Guðný Eiríksdóttir; Tamara B Harris; Lenore J Launer; Vilmundur Guðnason; Andrew E Arai Journal: Eur Heart J Date: 2019-02-07 Impact factor: 29.983
Authors: Einar Heiberg; Jane Sjögren; Martin Ugander; Marcus Carlsson; Henrik Engblom; Håkan Arheden Journal: BMC Med Imaging Date: 2010-01-11 Impact factor: 1.930
Authors: Eric Y Yang; Mohamad G Ghosn; Mohammad A Khan; Nickalaus L Gramze; Gerd Brunner; Faisal Nabi; Vijay Nambi; Sherif F Nagueh; Duc T Nguyen; Edward A Graviss; Erik B Schelbert; Christie M Ballantyne; William A Zoghbi; Dipan J Shah Journal: Circ Cardiovasc Imaging Date: 2019-12-16 Impact factor: 7.792
Authors: Mohammadali Habibi; Sanaz Samiei; Bharath Ambale Venkatesh; Anders Opdahl; Thomas M Helle-Valle; Mytra Zareian; Andre L C Almeida; Eui-Young Choi; Colin Wu; Alvaro Alonso; Susan R Heckbert; David A Bluemke; João A C Lima Journal: Circ Cardiovasc Imaging Date: 2016-08 Impact factor: 7.792
Authors: Jonathan A Hudson; Edith D Majonga; Rashida A Ferrand; Pablo Perel; Shirjel R Alam; Anoop S V Shah Journal: JAMA Date: 2022-09-13 Impact factor: 157.335
Authors: Wendy S Post; Katherine C Wu; Tess E Peterson; Christian Landon; Sabina A Haberlen; Fiona Bhondoekhan; Michael W Plankey; Frank J Palella; Damani A Piggott; Joseph B Margolick; Todd T Brown Journal: BMC Cardiovasc Disord Date: 2022-09-03 Impact factor: 2.174