Literature DB >> 33692684

Rational Drug Repurposing: Focus on Lysosomotropism, Targets in Disease Process, Drug Profile, and Pulmonary Tissue Accumulation in SARS-CoV-2 Infection/COVID-19.

Markus Blaess1, Lars Kaiser1,2, Oliver Sommerfeld3, Simone Rentschler1, René Csuk4, Hans-Peter Deigner1,5,6.   

Abstract

Entities:  

Keywords:  COVID-19; SARS-CoV-2; approved active compounds; cytokine storm syndrome; lysosome; lysosomotropic compounds; lysosomotropism; repurposing approved drugs

Year:  2020        PMID： 33692684      PMCID： PMC7938238          DOI： 10.3389/fphar.2020.584881

Source DB:  PubMed          Journal:  Front Pharmacol        ISSN： 1663-9812            Impact factor:   5.810


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  5 in total

Review 1.  Protection by metformin against severe Covid-19: An in-depth mechanistic analysis.

Authors:  Nicolas Wiernsperger; Abdallah Al-Salameh; Bertrand Cariou; Jean-Daniel Lalau
Journal:  Diabetes Metab       Date:  2022-05-31       Impact factor: 8.254

Review 2.  Potential Antiviral Strategy Exploiting Dependence of SARS-CoV-2 Replication on Lysosome-Based Pathway.

Authors:  Yungang Lan; Wenqi He; Gaili Wang; Zhenzhen Wang; Yuzhu Chen; Feng Gao; Deguang Song
Journal:  Int J Mol Sci       Date:  2022-05-31       Impact factor: 6.208

Review 3.  Resources and computational strategies to advance small molecule SARS-CoV-2 discovery: lessons from the pandemic and preparing for future health crises.

Authors:  Natesh Singh; Bruno O Villoutreix
Journal:  Comput Struct Biotechnol J       Date:  2021-04-26       Impact factor: 7.271

Review 4.  Drug triggered pruritus, rash, papules, and blisters - is AGEP a clash of an altered sphingolipid-metabolism and lysosomotropism of drugs accumulating in the skin?

Authors:  Markus Blaess; Lars Kaiser; Oliver Sommerfeld; René Csuk; Hans-Peter Deigner
Journal:  Lipids Health Dis       Date:  2021-11-08       Impact factor: 3.876

5.  Hydroxyzine Use and Mortality in Patients Hospitalized for COVID-19: A Multicenter Observational Study.

Authors:  Marina Sánchez-Rico; Frédéric Limosin; Raphaël Vernet; Nathanaël Beeker; Antoine Neuraz; Carlos Blanco; Mark Olfson; Cédric Lemogne; Pierre Meneton; Christel Daniel; Nicolas Paris; Alexandre Gramfort; Guillaume Lemaitre; Pedro De La Muela; Elisa Salamanca; Mélodie Bernaux; Ali Bellamine; Anita Burgun; Nicolas Hoertel
Journal:  J Clin Med       Date:  2021-12-15       Impact factor: 4.241
  5 in total

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