| Literature DB >> 33690265 |
Houriiyah Tegally1, Eduan Wilkinson1, Marta Giovanetti2,3, Arash Iranzadeh4, Vagner Fonseca1,3, Jennifer Giandhari1, Deelan Doolabh5, Sureshnee Pillay1, Emmanuel James San1, Nokukhanya Msomi6, Koleka Mlisana7,8, Anne von Gottberg9,10, Sibongile Walaza9,11, Mushal Allam9, Arshad Ismail9, Thabo Mohale9, Allison J Glass10,12, Susan Engelbrecht13, Gert Van Zyl13, Wolfgang Preiser13, Francesco Petruccione14,15, Alex Sigal16,17,18, Diana Hardie19, Gert Marais19, Nei-Yuan Hsiao19, Stephen Korsman19, Mary-Ann Davies20,21, Lynn Tyers5, Innocent Mudau5, Denis York22, Caroline Maslo23, Dominique Goedhals24, Shareef Abrahams25, Oluwakemi Laguda-Akingba25,26, Arghavan Alisoltani-Dehkordi27,28, Adam Godzik28, Constantinos Kurt Wibmer9, Bryan Trevor Sewell29, José Lourenço30, Luiz Carlos Junior Alcantara2,3, Sergei L Kosakovsky Pond31, Steven Weaver31, Darren Martin4,5, Richard J Lessells1,8, Jinal N Bhiman9,10, Carolyn Williamson5,8,19, Tulio de Oliveira32,33,34.
Abstract
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3-5. This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZulu-Natal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic data-which show rapid expansion and displacement of other lineages in several regions-suggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape6-8.Entities:
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Year: 2021 PMID： 33690265 DOI： 10.1038/s41586-021-03402-9
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962