Background: Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic response [1,2]. Here we present the international Observational Health Data Sciences and Informatics (OHDSI) [3] Characterizing Health Associated Risks, and Your Baseline Disease In SARS-COV-2 (CHARYBDIS) framework for standardisation and analysis of COVID-19 RWD. Methods: We conducted a descriptive cohort study using a federated network of data partners in the United States, Europe (the Netherlands, Spain, the UK, Germany, France and Italy) and Asia (South Korea and China). The study protocol and analytical package were released on 11 th June 2020 and are iteratively updated via GitHub [4]. Findings: We identified three non-mutually exclusive cohorts of 4,537,153 individuals with a clinical COVID-19 diagnosis or positive test, 886,193 hospitalized with COVID-19 , and 113,627 hospitalized with COVID-19 requiring intensive services . All comorbidities, symptoms, medications, and outcomes are described by cohort in aggregate counts, and are available in an interactive website: https://data.ohdsi.org/Covid19CharacterizationCharybdis/. Interpretation: CHARYBDIS findings provide benchmarks that contribute to our understanding of COVID-19 progression, management and evolution over time. This can enable timely assessment of real-world outcomes of preventative and therapeutic options as they are introduced in clinical practice.
Background: Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic response [1,2]. Here we present the international Observational Health Data Sciences and Informatics (OHDSI) [3] Characterizing Health Associated Risks, and Your Baseline Disease In SARS-COV-2 (CHARYBDIS) framework for standardisation and analysis of COVID-19 RWD. Methods: We conducted a descriptive cohort study using a federated network of data partners in the United States, Europe (the Netherlands, Spain, the UK, Germany, France and Italy) and Asia (South Korea and China). The study protocol and analytical package were released on 11 th June 2020 and are iteratively updated via GitHub [4]. Findings: We identified three non-mutually exclusive cohorts of 4,537,153 individuals with a clinical COVID-19 diagnosis or positive test, 886,193 hospitalized with COVID-19 , and 113,627 hospitalized with COVID-19 requiring intensive services . All comorbidities, symptoms, medications, and outcomes are described by cohort in aggregate counts, and are available in an interactive website: https://data.ohdsi.org/Covid19CharacterizationCharybdis/. Interpretation: CHARYBDIS findings provide benchmarks that contribute to our understanding of COVID-19 progression, management and evolution over time. This can enable timely assessment of real-world outcomes of preventative and therapeutic options as they are introduced in clinical practice.
Authors: J Marc Overhage; Patrick B Ryan; Christian G Reich; Abraham G Hartzema; Paul E Stang Journal: J Am Med Inform Assoc Date: 2011-10-28 Impact factor: 4.497
Authors: Martijn J Schuemie; M Soledad Cepeda; Marc A Suchard; Jianxiao Yang; Yuxi Tian; Alejandro Schuler; Patrick B Ryan; David Madigan; George Hripcsak Journal: Harv Data Sci Rev Date: 2020-01-31
Authors: Subha Madhavan; Lisa Bastarache; Jeffrey S Brown; Atul J Butte; David A Dorr; Peter J Embi; Charles P Friedman; Kevin B Johnson; Jason H Moore; Isaac S Kohane; Philip R O Payne; Jessica D Tenenbaum; Mark G Weiner; Adam B Wilcox; Lucila Ohno-Machado Journal: J Am Med Inform Assoc Date: 2021-02-15 Impact factor: 4.497
Authors: Vignesh Subbian; Anthony Solomonides; Melissa Clarkson; Vasiliki Nataly Rahimzadeh; Carolyn Petersen; Richard Schreiber; Paul R DeMuro; Prerna Dua; Kenneth W Goodman; Bonnie Kaplan; Ross Koppel; Christoph U Lehmann; Eric Pan; Yalini Senathirajah Journal: J Am Med Inform Assoc Date: 2021-01-15 Impact factor: 4.497
Authors: Michael G Kahn; Tiffany J Callahan; Juliana Barnard; Alan E Bauck; Jeff Brown; Bruce N Davidson; Hossein Estiri; Carsten Goerg; Erin Holve; Steven G Johnson; Siaw-Teng Liaw; Marianne Hamilton-Lopez; Daniella Meeker; Toan C Ong; Patrick Ryan; Ning Shang; Nicole G Weiskopf; Chunhua Weng; Meredith N Zozus; Lisa Schilling Journal: EGEMS (Wash DC) Date: 2016-09-11
Authors: Edward Burn; Seng Chan You; Anthony G Sena; Kristin Kostka; Hamed Abedtash; Maria Tereza F Abrahão; Amanda Alberga; Heba Alghoul; Osaid Alser; Thamir M Alshammari; Maria Aragon; Carlos Areia; Juan M Banda; Jaehyeong Cho; Aedin C Culhane; Alexander Davydov; Frank J DeFalco; Talita Duarte-Salles; Scott DuVall; Thomas Falconer; Sergio Fernandez-Bertolin; Weihua Gao; Asieh Golozar; Jill Hardin; George Hripcsak; Vojtech Huser; Hokyun Jeon; Yonghua Jing; Chi Young Jung; Benjamin Skov Kaas-Hansen; Denys Kaduk; Seamus Kent; Yeesuk Kim; Spyros Kolovos; Jennifer C E Lane; Hyejin Lee; Kristine E Lynch; Rupa Makadia; Michael E Matheny; Paras P Mehta; Daniel R Morales; Karthik Natarajan; Fredrik Nyberg; Anna Ostropolets; Rae Woong Park; Jimyung Park; Jose D Posada; Albert Prats-Uribe; Gowtham Rao; Christian Reich; Yeunsook Rho; Peter Rijnbeek; Lisa M Schilling; Martijn Schuemie; Nigam H Shah; Azza Shoaibi; Seokyoung Song; Matthew Spotnitz; Marc A Suchard; Joel N Swerdel; David Vizcaya; Salvatore Volpe; Haini Wen; Andrew E Williams; Belay B Yimer; Lin Zhang; Oleg Zhuk; Daniel Prieto-Alhambra; Patrick Ryan Journal: Nat Commun Date: 2020-10-06 Impact factor: 14.919
Authors: Christopher B Forrest; Kathleen M McTigue; Adrian F Hernandez; Lauren W Cohen; Henry Cruz; Kevin Haynes; Rainu Kaushal; Abel N Kho; Keith A Marsolo; Vinit P Nair; Richard Platt; Jon E Puro; Russell L Rothman; Elizabeth A Shenkman; Lemuel Russell Waitman; Neely A Williams; Thomas W Carton Journal: J Clin Epidemiol Date: 2020-09-28 Impact factor: 6.437
Authors: Melissa A Haendel; Christopher G Chute; Tellen D Bennett; David A Eichmann; Justin Guinney; Warren A Kibbe; Philip R O Payne; Emily R Pfaff; Peter N Robinson; Joel H Saltz; Heidi Spratt; Christine Suver; John Wilbanks; Adam B Wilcox; Andrew E Williams; Chunlei Wu; Clair Blacketer; Robert L Bradford; James J Cimino; Marshall Clark; Evan W Colmenares; Patricia A Francis; Davera Gabriel; Alexis Graves; Raju Hemadri; Stephanie S Hong; George Hripscak; Dazhi Jiao; Jeffrey G Klann; Kristin Kostka; Adam M Lee; Harold P Lehmann; Lora Lingrey; Robert T Miller; Michele Morris; Shawn N Murphy; Karthik Natarajan; Matvey B Palchuk; Usman Sheikh; Harold Solbrig; Shyam Visweswaran; Anita Walden; Kellie M Walters; Griffin M Weber; Xiaohan Tanner Zhang; Richard L Zhu; Benjamin Amor; Andrew T Girvin; Amin Manna; Nabeel Qureshi; Michael G Kurilla; Sam G Michael; Lili M Portilla; Joni L Rutter; Christopher P Austin; Ken R Gersing Journal: J Am Med Inform Assoc Date: 2021-03-01 Impact factor: 7.942