Nezahat Arzu Kayar1, Kemal Üstün2, Muammer Gözlü3,4, Seyfullah Haliloğlu5, Nilgün Özlem Alptekin6. 1. Department of Periodontology, Akdeniz University Faculty of Dentistry, 07058, Antalya, Turkey. nazu@hotmail.com. 2. Department of Periodontology, Akdeniz University Faculty of Dentistry, 07058, Antalya, Turkey. 3. Department of Periodontology, Selcuk University Faculty of Dentistry, Konya, Turkey. 4. Dentesthetic Oral and Dental Clinic, Konya, Turkey. 5. Department of Biochemistry, Selcuk University Faculty of Veterinary Medicine, Konya, Turkey. 6. Department of Periodontology, Baskent University Faculty of Dentistry, 06790, Ankara, Turkey.
Abstract
OBJECTIVE: Periodontitis may contribute to vascular damage, resulting in the destabilization of atherosclerotic plaque leading to acute coronary syndrome (ACS). In this study, we explored the effect of non-surgical periodontal treatment (NSPT) on cardiovascular blood biomarkers and gingival crevicular fluid (GCF) neutrophil elastase (NE) and α1-proteinase inhibitor (α-1PI) levels in periodontitis (P) participants with and without ACS. MATERIALS AND METHODS: Medical and dental examinations were performed to diagnose ACS and periodontitis, respectively. Seventeen patients with diagnosis of ACS and periodontitis were included in this study, as a test group (group ACS). Twenty-six age and sex-matched control patients with periodontitis (group P) were otherwise systemically healthy. Both groups received NSPT. Plasma levels of cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP), GCF NE activity, GCF α1-PI levels, and GCF NE/α1-PI rates were measured at baseline, at1st and 3rd months after NSPT. RESULTS: GCF NE activity/time (μU/30s) decreased significantly at 3rd month compared to baseline values in the Group P after NSPT. First and 3rd months after NSPT, in the Group P GCF α1-PI activity/time (pg/30s) was significantly higher than the Group ACS. Moreover GCF NE/α1-PI rates decreased significantly compared to baseline values at 1st and 3rd months after NSPT in the group P. CONCLUSION: NSPT yields decrease in NE/α1-PI rates. NE and its possible interactions with α1-PI may play a crucial role in both periodontitis and ACS. GCF α1PI activity/time (U/30s) can be a potential biomarker in management of periodontitis associated with ACS. CLINICAL RELEVANCE: The GCF α1-PI reduction may alter the immune-inflammatory response in patients with periodontitis and thus increase the risk of ACS. TRIAL REGISTRATION: Thai Clinical Trials.gov (NCT04785235).
OBJECTIVE:Periodontitis may contribute to vascular damage, resulting in the destabilization of atherosclerotic plaque leading to acute coronary syndrome (ACS). In this study, we explored the effect of non-surgical periodontal treatment (NSPT) on cardiovascular blood biomarkers and gingival crevicular fluid (GCF) neutrophil elastase (NE) and α1-proteinase inhibitor (α-1PI) levels in periodontitis (P) participants with and without ACS. MATERIALS AND METHODS: Medical and dental examinations were performed to diagnose ACS and periodontitis, respectively. Seventeen patients with diagnosis of ACS and periodontitis were included in this study, as a test group (group ACS). Twenty-six age and sex-matched control patients with periodontitis (group P) were otherwise systemically healthy. Both groups received NSPT. Plasma levels of cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP), GCF NE activity, GCF α1-PI levels, and GCF NE/α1-PI rates were measured at baseline, at1st and 3rd months after NSPT. RESULTS: GCF NE activity/time (μU/30s) decreased significantly at 3rd month compared to baseline values in the Group P after NSPT. First and 3rd months after NSPT, in the Group P GCF α1-PI activity/time (pg/30s) was significantly higher than the Group ACS. Moreover GCF NE/α1-PI rates decreased significantly compared to baseline values at 1st and 3rd months after NSPT in the group P. CONCLUSION: NSPT yields decrease in NE/α1-PI rates. NE and its possible interactions with α1-PI may play a crucial role in both periodontitis and ACS. GCF α1PI activity/time (U/30s) can be a potential biomarker in management of periodontitis associated with ACS. CLINICAL RELEVANCE: The GCF α1-PI reduction may alter the immune-inflammatory response in patients with periodontitis and thus increase the risk of ACS. TRIAL REGISTRATION: Thai Clinical Trials.gov (NCT04785235).
Authors: Emil V Kozarov; Brian R Dorn; Charles E Shelburne; William A Dunn; Ann Progulske-Fox Journal: Arterioscler Thromb Vasc Biol Date: 2005-01-20 Impact factor: 8.311
Authors: John M Liljestrand; Susanna Paju; Milla Pietiäinen; Kåre Buhlin; G Rutger Persson; Markku S Nieminen; Juha Sinisalo; Päivi Mäntylä; Pirkko J Pussinen Journal: Atherosclerosis Date: 2017-12-06 Impact factor: 5.162
Authors: Syed A H Bokhari; Ayyaz A Khan; Arshad K Butt; Mohammad Azhar; Mohammad Hanif; Mateen Izhar; Dimitris N Tatakis Journal: J Clin Periodontol Date: 2012-09-11 Impact factor: 8.728
Authors: E Roca-Millan; B González-Navarro; M-M Sabater-Recolons; A Marí-Roig; E Jané-Salas; J López-López Journal: Med Oral Patol Oral Cir Bucal Date: 2018-11-01