| Literature DB >> 33684669 |
Kyoo-A Lee1, Paul D Robbins1, Christina D Camell2.
Abstract
Aging is associated with the highest risk for morbidity and mortality to chronic or metabolic diseases, which are present in 50% of the elderly. Improving metabolic and immune function of the elderly would improve quality of life and reduce the risk for all other diseases. Tissue-resident macrophages and the NLRP3 inflammasome are established drivers of inflammaging and metabolic dysfunction. Energy-sensing signaling pathways connect sterile and metabolic inflammation with cellular senescence and tissue dysfunction. We discuss recent advances in the immunometabolism field. Common themes revealed by recent publications include the alterations in metabolic signaling (SIRTUIN, AMPK, or mTOR pathways) in aged immune cells, the impact of senescence on inflammaging and tissue dysfunction, and the age-related changes in metabolic tissues, especially adipose tissue, as an immunological organ. Promising gerotherapeutics are candidates to broadly target nutrient and energy sensing, inflammatory and senescence pathways, and have potential to improve healthspan and treat age-related diseases. Published by Elsevier Ltd.Entities:
Keywords: AMPK-mTOR pathway; Adipose tissue; Aging; Immunometabolism; Inflammaging; Macrophage; NAD metabolism; NLRP3 inflammasome; SIRTUIN pathway
Mesh：
Substances：
Year: 2021 PMID： 33684669 PMCID： PMC8481958 DOI： 10.1016/j.coph.2021.01.003
Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547