| Literature DB >> 33683900 |
Guilherme S Caleffi1, Juliana de O C Brum1,2, Angela T Costa1, Jorge L O Domingos3, Paulo R R Costa1.
Abstract
3-Arylidenechroman-4-ones and 2-arylidene-1-tetralones are hydrogenated to cis-benzylic alcohols in dr's and er's up to 99:1 via a C═C and C═O one-pot reduction in the presence of 2-5 mol % Noyori-Ikariya-type RuII chiral complexes and HCO2Na as a hydrogen source under asymmetric transfer hydrogenation-dynamic kinetic resolution (ATH-DKR) conditions. The oxidation of theses substrates resulted in the enantioselective synthesis of the natural homoisoflavanone dihydrobonducellin and its carba-analogues.Entities:
Year: 2021 PMID： 33683900 DOI： 10.1021/acs.joc.0c02981
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354