Hye Sung Han1, Ji Yeon Hong2, Tae Rin Kwon1, Sung Eun Lee1, Kwang Ho Yoo1, Sun Young Choi3, Beom Joon Kim1. 1. Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea. 2. Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea. 3. Department of Dermatology, Seoul Paik Hospital Inje University College of Medicine, Seoul, South Korea.
Abstract
BACKGROUND: Needle-free jet injectors are devices that deliver drugs using a high-speed jet without a needle. Recent studies have significantly increased our understanding of the mechanisms of needle-free jet injectors, and technical advancements have broadened the scope of application of the device. AIMS: We aimed to provide an up-to-date review of previous literature regarding the mechanism of action and clinical applications of needle-free jet injectors in dermatology field. METHODS: We conducted a PUBMED search for studies on needle-free jet injectors using the following parameters: "Pneumatic injector" OR "needleless injector" OR "needle-free injector" OR "jet injector." Among 191 results, 72 articles focusing on their mechanisms of action, cutaneous delivery patterns, and clinical applications in dermatology were selected for review. RESULTS: Significant clinical evidence has been published confirming the potential of needle-free jet injectors in treating various dermatologic conditions. In particular, these devices have the potential to be used in various skin remodeling treatment, especially in skin rejuvenation procedures by injecting various esthetic materials. CONCLUSION: As proven by accumulated experience, the applications of NFJIs are not restricted to vaccine or insulin delivery in dermatology field. However, this literature review shows that until now, there are no clinical guidelines that standardize the optimal parameters when using NFJIs on various clinical settings. Therefore, further studies should be performed in order to investigate the full potential of these devices in dermatology, to ensure safe and effective outcomes in clinical practice.
BACKGROUND: Needle-free jet injectors are devices that deliver drugs using a high-speed jet without a needle. Recent studies have significantly increased our understanding of the mechanisms of needle-free jet injectors, and technical advancements have broadened the scope of application of the device. AIMS: We aimed to provide an up-to-date review of previous literature regarding the mechanism of action and clinical applications of needle-free jet injectors in dermatology field. METHODS: We conducted a PUBMED search for studies on needle-free jet injectors using the following parameters: "Pneumatic injector" OR "needleless injector" OR "needle-free injector" OR "jet injector." Among 191 results, 72 articles focusing on their mechanisms of action, cutaneous delivery patterns, and clinical applications in dermatology were selected for review. RESULTS: Significant clinical evidence has been published confirming the potential of needle-free jet injectors in treating various dermatologic conditions. In particular, these devices have the potential to be used in various skin remodeling treatment, especially in skin rejuvenation procedures by injecting various esthetic materials. CONCLUSION: As proven by accumulated experience, the applications of NFJIs are not restricted to vaccine or insulin delivery in dermatology field. However, this literature review shows that until now, there are no clinical guidelines that standardize the optimal parameters when using NFJIs on various clinical settings. Therefore, further studies should be performed in order to investigate the full potential of these devices in dermatology, to ensure safe and effective outcomes in clinical practice.
Authors: Michele Schlich; Luca Casula; Aurora Musa; Rosa Pireddu; Giulia Pitzanti; Maria Cristina Cardia; Donatella Valenti; Salvatore Marceddu; Anna Maria Fadda; Maria Antonietta De Luca; Chiara Sinico; Francesco Lai Journal: Pharmaceutics Date: 2022-05-19 Impact factor: 6.525