Kerryn W Reding1,2, Khristine Ghemigian3, Salvatore Carbone4, Ralph D'Agostino5, Jennifer H Jordan4,6, Giselle Meléndez3,7, Zanetta S Lamar8, Heidi D Klepin8, Alexandra Thomas8, Dale Langford9, Sujethra Vasu3, W Gregory Hundley3,4. 1. Department of Biobehavioral Nursing and Health Informatics University of Washington School of Nursing Washington Seattle USA. 2. Division of Public Health Sciences Fred Hutchinson Cancer Research Center Washington Seattle USA. 3. Department of Internal Medicine Section on Cardiovascular Medicine Wake Forest University Winston-Salem North Carolina USA. 4. Department of Internal Medicine VCU Pauley Heart Center Virginia Commonwealth University School of Medicine Richmound Virginia USA. 5. Department of Biostatistical Sciences Wake Forest University Winston-Salem North Carolina USA. 6. Department of Biomedical Engineering Virginia Commonwealth University Richmound Virginia USA. 7. Department of Pathology Section on Comparative Medicine Wake Forest University Winston-Salem North Carolina USA. 8. Department of Internal Medicine Section on Hematology and Oncology Wake Forest University Winston-Salem North Carolina USA. 9. Department of Anesthesiology and Pain Medicine University of Washington School of Medicine Washington Seattle USA.
Abstract
OBJECTIVES: Prior studies have identified a relationship between body mass index (BMI) and intraperitoneal (IP) fat with heart failure; however, in prior studies of cancer patients receiving potentially cardiotoxic chemotherapy, elevations in BMI have not necessarily been associated with decrements in heart function. This study tested the hypothesis that IP fat may be associated with left ventricular ejection fraction (LVEF) decline among cancer patients receiving potentially cardiotoxic chemotherapy. METHODS: In this prospective study of 61 cancer patients (23 breast cancer, 32 lymphoma, and 6 sarcoma), IP fat and other assessments of body composition, and changes in LVEF from pre- to postcancer treatment using noninvasive magnetic resonance imaging was ascertained. RESULTS: After accounting for age, baseline LVEF, and confounding variables, pre- to 24-month post-treatment LVEF changes were inversely correlated with IP fat (r = -0.33; p = 0.02) and positively correlated with measures of subcutaneous (SQ) fat (r = 0.33; p = 0.01). These LVEF changes were not correlated with BMI (r = 0.12; p = 0.37). CONCLUSION: Among patients receiving potentially cardiotoxic chemotherapy, pretreatment IP fat was associated with subsequent declines in LVEF. There was no association between BMI and LVEF decline. These findings may be related to a potential protective effect of SQ fat.
OBJECTIVES: Prior studies have identified a relationship between body mass index (BMI) and intraperitoneal (IP) fat with heart failure; however, in prior studies of cancer patients receiving potentially cardiotoxic chemotherapy, elevations in BMI have not necessarily been associated with decrements in heart function. This study tested the hypothesis that IP fat may be associated with left ventricular ejection fraction (LVEF) decline among cancer patients receiving potentially cardiotoxic chemotherapy. METHODS: In this prospective study of 61 cancer patients (23 breast cancer, 32 lymphoma, and 6 sarcoma), IP fat and other assessments of body composition, and changes in LVEF from pre- to postcancer treatment using noninvasive magnetic resonance imaging was ascertained. RESULTS: After accounting for age, baseline LVEF, and confounding variables, pre- to 24-month post-treatment LVEF changes were inversely correlated with IP fat (r = -0.33; p = 0.02) and positively correlated with measures of subcutaneous (SQ) fat (r = 0.33; p = 0.01). These LVEF changes were not correlated with BMI (r = 0.12; p = 0.37). CONCLUSION: Among patients receiving potentially cardiotoxic chemotherapy, pretreatment IP fat was associated with subsequent declines in LVEF. There was no association between BMI and LVEF decline. These findings may be related to a potential protective effect of SQ fat.
Authors: Susan R Heckbert; Wendy Post; Gregory D N Pearson; Donna K Arnett; Antoinette S Gomes; Michael Jerosch-Herold; W Gregory Hundley; Joao A Lima; David A Bluemke Journal: J Am Coll Cardiol Date: 2006-11-09 Impact factor: 24.094
Authors: Kerryn W Reding; Nathaniel S O'Connell; Ralph B D'Agostino; William Hundley; Alexander R Lucas; Amy C Ladd; Jennifer H Jordan; Emily M Heiston; Yaorong Ge; W Gregory Hundley Journal: Cardiooncology Date: 2021-05-08
Authors: Kerryn W Reding; Richard K Cheng; Alexi Vasbinder; Roberta M Ray; Ana Barac; Charles B Eaton; Nazmus Saquib; Aladdin H Shadyab; Michael S Simon; Dale Langford; Mary Branch; Bette Caan; Garnet Anderson Journal: JACC CardioOncol Date: 2022-03-15