Vikas Yadav1, Deepti Dabar2, Akhil D Goel3, Mohan Bairwa4, Akanksha Sood5, Pankaj Prasad2, Sanjay S Agarwal1, Sunil Nandeshwar1. 1. Atal Bihari Vajpayee Government Medical College, Vidisha, India. 2. All India Institute of Medical Sciences, Bhopal, India. 3. All India Institute of Medical Sciences, Jodhpur, India. 4. All India Institute of Medical Sciences, New Delhi, India. 5. St. Mary's Hospital, Oxford Road, Manchester, UK.
Abstract
INTRODUCTION: This meta-analysis was conducted to estimate the prevalence of hypothyroidism among pregnant women in India. METHODS: We searched PubMed, Web of Science, Scopus, Google Scholar, and Shodhganga (Indian thesis repository) for observational studies, providing prevalence of hypothyroidism among pregnant women in India. Systematic study selection and data extraction procedures were followed. Quality assessment of each study was done using JBI critical appraisal checklist. The random effects model was used for pooling the effect sizes. Publication bias was assessed using the funnel plot and rank correlation test. I 2 statistics was used to measure heterogeneity across the studies. Heterogeneity in the pooled estimates was further explored with subgroup analyses and meta-regression analysis. RESULTS: Sixty-one studies were found eligible and included in this review. The pooled estimate of the prevalence of hypothyroidism in pregnant women was 11.07% (95% CI: 8.79-13.84, I 2 = 99%). Pooled prevalence estimates of subclinical and overt hypothyroidism are 9.51% (95% CI: 7.48-12.04, I 2 = 98%) and 2.74% (95% CI: 2.08-3.58, I 2 = 94%). CONCLUSION: We documented 11.07% pooled prevalence of hypothyroidism in pregnant women in India.
INTRODUCTION: This meta-analysis was conducted to estimate the prevalence of hypothyroidism among pregnant women in India. METHODS: We searched PubMed, Web of Science, Scopus, Google Scholar, and Shodhganga (Indian thesis repository) for observational studies, providing prevalence of hypothyroidism among pregnant women in India. Systematic study selection and data extraction procedures were followed. Quality assessment of each study was done using JBI critical appraisal checklist. The random effects model was used for pooling the effect sizes. Publication bias was assessed using the funnel plot and rank correlation test. I 2 statistics was used to measure heterogeneity across the studies. Heterogeneity in the pooled estimates was further explored with subgroup analyses and meta-regression analysis. RESULTS: Sixty-one studies were found eligible and included in this review. The pooled estimate of the prevalence of hypothyroidism in pregnant women was 11.07% (95% CI: 8.79-13.84, I 2 = 99%). Pooled prevalence estimates of subclinical and overt hypothyroidism are 9.51% (95% CI: 7.48-12.04, I 2 = 98%) and 2.74% (95% CI: 2.08-3.58, I 2 = 94%). CONCLUSION: We documented 11.07% pooled prevalence of hypothyroidism in pregnant women in India.
Authors: W C Allan; J E Haddow; G E Palomaki; J R Williams; M L Mitchell; R J Hermos; J D Faix; R Z Klein Journal: J Med Screen Date: 2000 Impact factor: 2.136
Authors: V J Pop; J L Kuijpens; A L van Baar; G Verkerk; M M van Son; J J de Vijlder; T Vulsma; W M Wiersinga; H A Drexhage; H L Vader Journal: Clin Endocrinol (Oxf) Date: 1999-02 Impact factor: 3.478
Authors: Emmy van den Boogaard; Rosa Vissenberg; Jolande A Land; Madelon van Wely; Joris A M van der Post; Mariette Goddijn; Peter H Bisschop Journal: Hum Reprod Update Date: 2011-05-28 Impact factor: 15.610
Authors: Erik K Alexander; Elizabeth N Pearce; Gregory A Brent; Rosalind S Brown; Herbert Chen; Chrysoula Dosiou; William A Grobman; Peter Laurberg; John H Lazarus; Susan J Mandel; Robin P Peeters; Scott Sullivan Journal: Thyroid Date: 2017-03 Impact factor: 6.568
Authors: Marcos Abalovich; Nobuyuki Amino; Linda A Barbour; Rhoda H Cobin; Leslie J De Groot; Daniel Glinoer; Susan J Mandel; Alex Stagnaro-Green Journal: J Clin Endocrinol Metab Date: 2007-08 Impact factor: 5.958