Literature DB >> 3368020

Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein.

C B Eap1, C Cuendet, P Baumann.   

Abstract

The S- and F-forms of alpha-1 acid glycoprotein (AAG) variants have been isolated by isoelectric focusing with immobilines from commercially available AAG. In equilibrium dialysis experiments using a multicompartmental system, a higher affinity for various basic drugs has been found with S- in comparison with F-AAG: Amitriptyline, nortriptyline, imipramine, desipramine, trimipramine, methadone, thioridazine, clomipramine, desmethylclomipramine, and maprotiline. The selectivity (binding to S- vs. F-AAG) is the most pronounced for methadone and the lowest for thioridazine, while it is absent for the acidic drug mephenytoin.

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Year:  1988        PMID： 3368020     DOI： 10.1007/bf00169251

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  31 in total

1.  THE ALPHA-1-ACID GLYCOPROTEIN VARIANTS OF NORMAL CAUCASIAN AND JAPANESE INDIVIDUALS.

Authors:  K SCHMID; K TOKITA; H YOSHIZAKI
Journal:  J Clin Invest       Date:  1965-08       Impact factor: 14.808

2.  Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9.

Authors:  M Rocchi; L Roncuzzi; R Santamaria; N Archidiacono; L Dente; G Romeo
Journal:  Hum Genet       Date:  1986-09       Impact factor: 4.132

3.  Characterization of drug distribution and binding competition by two-chamber and multi-chamber distribution dialysis.

Authors:  M H Bickel; R M Raaflaub; M Hellmüller; E J Stauffer
Journal:  J Pharm Sci       Date:  1987-01       Impact factor: 3.534

4.  The binding of chemically different psychotropic drugs to alpha 1-acid glycoprotein.

Authors:  J Schley; B Müller-Oerlinghausen
Journal:  Pharmacopsychiatria       Date:  1983-05

5.  Observations on the thermostability of orosomucoid.

Authors:  H B Halsall; T L Kirley
Journal:  Biochem Biophys Res Commun       Date:  1981-09-30       Impact factor: 3.575

6.  Inheritance of human alpha-1-acid glycoprotein (orosomucoid) variants.

Authors:  A M Johnson; K Schmid; C A Alper
Journal:  J Clin Invest       Date:  1969-12       Impact factor: 14.808

7.  Steroid-protein interactions. XXXIV. Chemical modification of alpha1-acid glycoprotein for characterization of the progesterone binding site.

Authors:  T Kute; U Westphal
Journal:  Biochim Biophys Acta       Date:  1976-01-20

8.  Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasma.

Authors:  M K Romach; K M Piafsky; J G Abel; V Khouw; E M Sellers
Journal:  Clin Pharmacol Ther       Date:  1981-02       Impact factor: 6.875

9.  Imipramine binding to alpha-1-acid glycoprotein in normal subjects and cardiac patients.

Authors:  D I Freilich; E G Giardina
Journal:  Clin Pharmacol Ther       Date:  1984-05       Impact factor: 6.875

10.  Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein.

Authors:  D G Ferry; N B Caplan; L X Cubeddu
Journal:  J Pharm Sci       Date:  1986-02       Impact factor: 3.534
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  8 in total

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Review 2.  Drug binding in plasma. A summary of recent trends in the study of drug and hormone binding.

Authors:  F Hervé; S Urien; E Albengres; J C Duché; J P Tillement
Journal:  Clin Pharmacokinet       Date:  1994-01       Impact factor: 6.447

3.  Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.

Authors:  D J Foster; A A Somogyi; K R Dyer; J M White; F Bochner
Journal:  Br J Clin Pharmacol       Date:  2000-11       Impact factor: 4.335

4.  Evidence for differences in the binding of drugs to the two main genetic variants of human alpha 1-acid glycoprotein.

Authors:  F Herve; E Gomas; J C Duche; J P Tillement
Journal:  Br J Clin Pharmacol       Date:  1993-09       Impact factor: 4.335

5.  Similar effect of oxidation deficiency (debrisoquine polymorphism) and quinidine on the apparent volume of distribution of (+/-)-metoprolol.

Authors:  T D Leemann; K P Devi; P Dayer
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

6.  Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein.

Authors:  Mohammad A K Azad; Johnny X Huang; Matthew A Cooper; Kade D Roberts; Philip E Thompson; Roger L Nation; Jian Li; Tony Velkov
Journal:  Biochem Pharmacol       Date:  2012-05-12       Impact factor: 5.858

7.  Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations.

Authors:  Johnny X Huang; Matthew A Cooper; Mark A Baker; Mohammad A K Azad; Roger L Nation; Jian Li; Tony Velkov
Journal:  J Mol Recognit       Date:  2012-12       Impact factor: 2.137

Review 8.  An overview of albumin and alpha-1-acid glycoprotein main characteristics: highlighting the roles of amino acids in binding kinetics and molecular interactions.

Authors:  Michel Bteich
Journal:  Heliyon       Date:  2019-11-21
  8 in total

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