Weibin Wang1, Xingyun Su2, Yongfeng Ding2, Weina Fan3, Weibin Zhou4, Junwei Su5, Zhendong Chen1, Hong Zhao5, Kaijin Xu5, Qin Ni5, Xiaowei Xu5, Yunqing Qiu5, Lisong Teng1. 1. Department of Surgical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 2. Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 3. Department of Intensive Care Unit (ICU), The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 4. Department of Endocrinology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 5. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Abstract
Purpose: The novel coronavirus COVID-19, has caused a worldwide pandemic, impairing several human organs and systems. Whether COVID-19 affects human thyroid function remains unknown. Methods: Eighty-four hospitalized COVID-19 patients in the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China) were retrospectively enrolled in this study, among which 22 cases had complete records of thyroid hormones. In addition, 91 other patients with pneumonia and 807 healthy subjects were included as controls. Results: We found that levels of total triiodothyronine (TT3) and thyroid stimulating hormone (TSH) were lower in COVID-19 patients than healthy group (p < 0.001). Besides, TSH level in COVID-19 patients was obviously lower than non-COVID-19 patients (p < 0.001). Within the group of COVID-19, 61.9% (52/84) patients presented with thyroid function abnormalities and the proportion of thyroid dysfunction was higher in severe cases than mild/moderate cases (74.6 vs. 23.8%, p < 0.001). Patients with thyroid dysfunction tended to have longer viral nucleic acid cleaning time (14.1 ± 9.4 vs. 10.6 ± 8.3 days, p = 0.088). To note, thyroid dysfunction was also associated with decreased lymphocytes (p < 0.001) and increased CRP (p = 0.002). The correlation between TT3 and TSH level seemed to be positive rather than negative in the early stage, and gradually turned to be negatively related over time. Conclusion: Thyroid function abnormalities are common in COVID-19 patients, especially in severe cases. This might be partially explained by nonthyroidal illness syndrome.
Purpose: The novel coronavirusCOVID-19, has caused a worldwide pandemic, impairing several human organs and systems. Whether COVID-19 affects human thyroid function remains unknown. Methods: Eighty-four hospitalized COVID-19patients in the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China) were retrospectively enrolled in this study, among which 22 cases had complete records of thyroid hormones. In addition, 91 other patients with pneumonia and 807 healthy subjects were included as controls. Results: We found that levels of total triiodothyronine (TT3) and thyroid stimulating hormone (TSH) were lower in COVID-19patients than healthy group (p < 0.001). Besides, TSH level in COVID-19patients was obviously lower than non-COVID-19patients (p < 0.001). Within the group of COVID-19, 61.9% (52/84) patients presented with thyroid function abnormalities and the proportion of thyroid dysfunction was higher in severe cases than mild/moderate cases (74.6 vs. 23.8%, p < 0.001). Patients with thyroid dysfunction tended to have longer viral nucleic acid cleaning time (14.1 ± 9.4 vs. 10.6 ± 8.3 days, p = 0.088). To note, thyroid dysfunction was also associated with decreased lymphocytes (p < 0.001) and increased CRP (p = 0.002). The correlation between TT3 and TSH level seemed to be positive rather than negative in the early stage, and gradually turned to be negatively related over time. Conclusion:Thyroid function abnormalities are common in COVID-19patients, especially in severe cases. This might be partially explained by nonthyroidal illness syndrome.
Authors: David Tak Wai Lui; Chi Ho Lee; Wing Sun Chow; Alan Chun Hong Lee; Anthony Raymond Tam; Polly Pang; Tip Yin Ho; Chloe Yu Yan Cheung; Carol Ho Yi Fong; Chun Yiu Law; Kelvin Kai Wang To; Ching Wan Lam; Kathryn Choon Beng Tan; Yu Cho Woo; Ivan Fan Ngai Hung; Karen Siu Ling Lam Journal: Front Endocrinol (Lausanne) Date: 2022-01-13 Impact factor: 5.555