Hans Torvild Kittilsen1, Sannija Goleva-Fjellet2, Baard Ingegerdsson Freberg1,3,4, Iver Nicolaisen1, Eva Maria Støa1, Solfrid Bratland-Sanda1, Jan Helgerud5,6, Eivind Wang5,7,8, Mona Sæbø2, Øyvind Støren1. 1. Department of Sport and Outdoor Life Studies, University of South-Eastern Norway, Bø, Norway. 2. Department of Natural Sciences and Environmental Health, University of South-Eastern Norway, Bø, Norway. 3. The Norwegian Biathlon Association, Oslo, Norway. 4. Top Sports Medical Office, Tønsberg, Norway. 5. Department of Circulation and Medical Imaging, Faculty of Medicine Trondheim, Norwegian University of Science and Technology, Trondheim, Norway. 6. Myworkout, Medical Rehabilitation Centre, Trondheim, Norway. 7. Faculty of Health and Social Sciences, Molde University College, Molde, Norway. 8. Division of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States.
Abstract
PURPOSE: The present study aimed to investigate the potential impact of age, gender, baseline strength, and selected candidate polymorphisms on maximal strength training (MST) adaptations. METHODS: A total of 49 subjects (22 men and 27 women) aged 20-76 years, divided into five age groups, completed an 8 weeks MST intervention. Each MST session consisted of 4 sets with 4 repetitions at ∼85-90% of one-repetition maximum (1RM) intensity in leg-press, three times per week. 1RM was tested pre and post the intervention and blood samples were drawn to genotype candidate polymorphisms ACE I/D (rs1799752), ACTN3 R577X (rs1815739), and PPARGC1A Gly482Ser (rs8192678). RESULTS: All age groups increased leg-press 1RM (p < 0.01), with a mean improvement of 24.2 ± 14.0%. There were no differences in improvements between the five age groups or between male and female participants, and there were no non-responders. Baseline strength status did not correlate with 1RM improvements. PPARGC1A rs8192678 T allele carriers had a 15% higher age- and gender corrected baseline 1RM than the CC genotype (p < 0.05). C allele carriers improved 1RM (%) by 34.2% more than homozygotes for the T allele (p < 0.05). CONCLUSION: To the best of our knowledge, this is the first study to report improvement in leg-press maximal strength regardless of gender, baseline strength status in all age groups. The present study is also first to demonstrate an association between the PPARGC1A rs8192678 and maximal strength and its trainability in a moderately trained cohort. MST may be beneficial for good health and performance of all healthy individuals.
PURPOSE: The present study aimed to investigate the potential impact of age, gender, baseline strength, and selected candidate polymorphisms on maximal strength training (MST) adaptations. METHODS: A total of 49 subjects (22 men and 27 women) aged 20-76 years, divided into five age groups, completed an 8 weeks MST intervention. Each MST session consisted of 4 sets with 4 repetitions at ∼85-90% of one-repetition maximum (1RM) intensity in leg-press, three times per week. 1RM was tested pre and post the intervention and blood samples were drawn to genotype candidate polymorphisms ACE I/D (rs1799752), ACTN3 R577X (rs1815739), and PPARGC1A Gly482Ser (rs8192678). RESULTS: All age groups increased leg-press 1RM (p < 0.01), with a mean improvement of 24.2 ± 14.0%. There were no differences in improvements between the five age groups or between male and female participants, and there were no non-responders. Baseline strength status did not correlate with 1RM improvements. PPARGC1A rs8192678 T allele carriers had a 15% higher age- and gender corrected baseline 1RM than the CC genotype (p < 0.05). C allele carriers improved 1RM (%) by 34.2% more than homozygotes for the T allele (p < 0.05). CONCLUSION: To the best of our knowledge, this is the first study to report improvement in leg-press maximal strength regardless of gender, baseline strength status in all age groups. The present study is also first to demonstrate an association between the PPARGC1A rs8192678 and maximal strength and its trainability in a moderately trained cohort. MST may be beneficial for good health and performance of all healthy individuals.
Authors: John P Wagle; Kevin M Carroll; Aaron J Cunanan; Alexander Wetmore; Christopher B Taber; Brad H DeWeese; Kimitake Sato; Charles A Stuart; Michael H Stone Journal: J Strength Cond Res Date: 2021-03-01 Impact factor: 3.775
Authors: Jan-Michael Johansen; Sannija Goleva-Fjellet; Arnstein Sunde; Lars Erik Gjerløw; Lars Arne Skeimo; Baard I Freberg; Mona Sæbø; Jan Helgerud; Øyvind Støren Journal: Front Physiol Date: 2020-10-26 Impact factor: 4.566