Literature DB >> 33679412

Drug-Drug Interactions at Organic Cation Transporter 1.

Shiwei Zhou1,2,3, Sujuan Zeng1, Yan Shu1,2.   

Abstract

The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.
Copyright © 2021 Zhou, Zeng and Shu.

Entities:  

Keywords:  OCT1; drug-drug interaction; inhibitor; organic cation transporters; substrate

Year:  2021        PMID： 33679412      PMCID： PMC7925875          DOI： 10.3389/fphar.2021.628705

Source DB:  PubMed          Journal:  Front Pharmacol        ISSN： 1663-9812            Impact factor:   5.810


  3 in total

Review 1.  Pharmacogenomics and circadian rhythms as mediators of cardiovascular drug-drug interactions.

Authors:  Yong-Jian Geng; Rosalinda Madonna; Ramon C Hermida; Michael H Smolensky
Journal:  Curr Res Pharmacol Drug Discov       Date:  2021-05-06

2.  MPP+-Induced Changes in Cellular Impedance as a Measure for Organic Cation Transporter (SLC22A1-3) Activity and Inhibition.

Authors:  Tamara A M Mocking; Hubert J Sijben; Yimé W Vermeulen; Adriaan P IJzerman; Laura H Heitman
Journal:  Int J Mol Sci       Date:  2022-01-21       Impact factor: 5.923

3.  Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1-3 and Human Plasma Membrane Monoamine Transporter.

Authors:  Thomas J F Angenoorth; Stevan Stankovic; Marco Niello; Marion Holy; Simon D Brandt; Harald H Sitte; Julian Maier
Journal:  Int J Mol Sci       Date:  2021-11-30       Impact factor: 6.208
  3 in total

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