Literature DB >> 33677727

Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study.

Morten Thorsen1,2,3,4, Niels Bilenberg5,6, Lena Thorsen7,8, Tanja Maria Michel7,9,6.   

Abstract

Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Autism Spectrum Disorder; Oxidative Stress; Sex; Superoxide Dismutase; Xanthine Oxidase

Mesh：

Substances：

Year:  2021        PMID： 33677727     DOI： 10.1007/s10803-021-04897-x

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  20 in total

1.  Expression and oxidative modifications of plasma proteins in autism spectrum disorders: Interplay between inflammatory response and lipid peroxidation.

Authors:  Alessio Cortelazzo; Claudio De Felice; Roberto Guerranti; Cinzia Signorini; Silvia Leoncini; Gloria Zollo; Roberto Leoncini; Anna Maria Timperio; Lello Zolla; Lucia Ciccoli; Joussef Hayek
Journal:  Proteomics Clin Appl       Date:  2016-06-27       Impact factor: 3.494

2.  Rare single nucleotide polymorphisms in the regulatory regions of the superoxide dismutase genes in autism spectrum disorder.

Authors:  Jernej Kovač; Marta Macedoni Lukšič; Katarina Trebušak Podkrajšek; Gašper Klančar; Tadej Battelino
Journal:  Autism Res       Date:  2013-10-23       Impact factor: 5.216

3.  T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains.

Authors:  Marcello M DiStasio; Ikue Nagakura; Monica J Nadler; Matthew P Anderson
Journal:  Ann Neurol       Date:  2019-11-04       Impact factor: 10.422

Review 4.  Diagnosis of autism spectrum disorder: reconciling the syndrome, its diverse origins, and variation in expression.

Authors:  John N Constantino; Tony Charman
Journal:  Lancet Neurol       Date:  2015-10-20       Impact factor: 44.182

Review 5.  How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis.

Authors:  Richard Deth; Christina Muratore; Jorge Benzecry; Verna-Ann Power-Charnitsky; Mostafa Waly
Journal:  Neurotoxicology       Date:  2007-10-13       Impact factor: 4.294

Review 6.  The epidemiology and global burden of autism spectrum disorders.

Authors:  A J Baxter; T S Brugha; H E Erskine; R W Scheurer; T Vos; J G Scott
Journal:  Psychol Med       Date:  2014-08-11       Impact factor: 7.723

7.  Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum.

Authors:  Catherine Edmonson; Mark N Ziats; Owen M Rennert
Journal:  Mol Autism       Date:  2014-01-10       Impact factor: 7.509

8.  Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation.

Authors:  Daniel P Howsmon; Uwe Kruger; Stepan Melnyk; S Jill James; Juergen Hahn
Journal:  PLoS Comput Biol       Date:  2017-03-16       Impact factor: 4.475

9.  Evidence of neurodegeneration in autism spectrum disorder.

Authors:  Janet K Kern; David A Geier; Lisa K Sykes; Mark R Geier
Journal:  Transl Neurodegener       Date:  2013-08-08       Impact factor: 8.014

10.  Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders.

Authors:  Maria Fiorentino; Anna Sapone; Stefania Senger; Stephanie S Camhi; Sarah M Kadzielski; Timothy M Buie; Deanna L Kelly; Nicola Cascella; Alessio Fasano
Journal:  Mol Autism       Date:  2016-11-29       Impact factor: 7.509
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  5 in total

1.  Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes.

Authors:  Mirolyuba Ilieva; Blanca Irene Aldana; Kasper Tore Vinten; Sonja Hohmann; Thomas William Woofenden; Renate Lukjanska; Helle S Waagepetersen; Tanja Maria Michel
Journal:  Mol Psychiatry       Date:  2022-05-26       Impact factor: 15.992

2.  Superoxide dismutase isozymes in cerebral organoids from autism spectrum disorder patients.

Authors:  Morten Ejlersen; Mirolyuba Ilieva; Tanja Maria Michel
Journal:  J Neural Transm (Vienna)       Date:  2022-03-09       Impact factor: 3.850

3.  Altered Blood Brain Barrier Permeability and Oxidative Stress in Cntnap2 Knockout Rat Model.

Authors:  Idil Memis; Rahul Mittal; Emily Furar; Isaiah White; Rebecca S Eshraghi; Jeenu Mittal; Adrien A Eshraghi
Journal:  J Clin Med       Date:  2022-05-11       Impact factor: 4.964

4.  DNA Methylation Profiles of GAD1 in Human Cerebral Organoids of Autism Indicate Disrupted Epigenetic Regulation during Early Development.

Authors:  Georgina Pearson; Chenchen Song; Sonja Hohmann; Tatyana Prokhorova; Tanja Maria Sheldrick-Michel; Thomas Knöpfel
Journal:  Int J Mol Sci       Date:  2022-08-16       Impact factor: 6.208

5.  Serum Vitamin D, Folate and Fatty Acid Levels in Children with Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.

Authors:  Maria Carmen Gallardo-Carrasco; José Antonio Jiménez-Barbero; María Del Mar Bravo-Pastor; David Martin-Castillo; María Sánchez-Muñoz
Journal:  J Autism Dev Disord       Date:  2021-11-03
  5 in total

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