BACKGROUND: Nikkomycin Z is a competitive inhibitor of chitin synthase-an enzyme needed for synthesis of the fungal cell wall. Nikkomycin Z shows promise as a treatment for coccidioidomycoses and mixed activity has been described against other fungi and yeast. To our knowledge, it has not previously been tested against the emerging fungal pathogen Candida auris. OBJECTIVES: To determine the in vitro activity of nikkomycin Z against C. auris. METHODS: Nikkomycin Z was tested by broth microdilution against a panel of 100 isolates of genetically diverse C. auris from around the world. RESULTS: Nikkomycin Z showed mixed activity against the tested isolates, with an MIC range of 0.125 to >64 mg/L. The MIC50 and MIC90 were 2 and 32 mg/L, respectively. CONCLUSIONS: These findings suggest nikkomycin Z has in vitro activity against some, but not all isolates of C. auris. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.
BACKGROUND:Nikkomycin Z is a competitive inhibitor of chitin synthase-an enzyme needed for synthesis of the fungal cell wall. Nikkomycin Z shows promise as a treatment for coccidioidomycoses and mixed activity has been described against other fungi and yeast. To our knowledge, it has not previously been tested against the emerging fungal pathogen Candida auris. OBJECTIVES: To determine the in vitro activity of nikkomycin Z against C. auris. METHODS:Nikkomycin Z was tested by broth microdilution against a panel of 100 isolates of genetically diverse C. auris from around the world. RESULTS:Nikkomycin Z showed mixed activity against the tested isolates, with an MIC range of 0.125 to >64 mg/L. The MIC50 and MIC90 were 2 and 32 mg/L, respectively. CONCLUSIONS: These findings suggest nikkomycin Z has in vitro activity against some, but not all isolates of C. auris. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Authors: Garima Shahi; Mohit Kumar; Andrzej S Skwarecki; Matt Edmondson; Atanu Banerjee; Jane Usher; Neil A R Gow; Sławomir Milewski; Rajendra Prasad Journal: Cell Surf Date: 2022-02-25
Authors: Vanice Rodrigues Poester; Lívia Silveira Munhoz; Jéssica Louise Benelli; Aryse Martins Melo; Abdullah M S Al-Hatmi; David J Larwood; Marife Martinez; David A Stevens; Melissa Orzechowski Xavier Journal: J Fungi (Basel) Date: 2022-07-25