Literature DB >> 33676022

Pseudomonas aeruginosa elastase (LasB) as a therapeutic target.

Martin J Everett1, David T Davies2.   

Abstract

Why is P. aeruginosa LasB elastase an attractive target for antivirulence therapy and what is the state-of-the art in LasB inhibitor design and development?
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2021        PMID： 33676022     DOI： 10.1016/j.drudis.2021.02.026

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  7 in total

1.  Presence of quorum sensing system, virulence genes, biofilm formation and relationship among them and class 1 integron in carbapenem-resistant clinical Pseudomonas aeruginosa isolates.

Authors:  Ceren Başkan; Belgin Sırıken; Enis Fuat Tüfekci; Çetin Kılınç; Ömer Ertürk; İrfan Erol
Journal:  Arch Microbiol       Date:  2022-07-08       Impact factor: 2.667

Review 2.  Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics.

Authors:  Shugang Qin; Wen Xiao; Chuanmin Zhou; Qinqin Pu; Xin Deng; Lefu Lan; Haihua Liang; Xiangrong Song; Min Wu
Journal:  Signal Transduct Target Ther       Date:  2022-06-25

3.  Clinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice.

Authors:  Yajie Zhu; Xiaoli Ge; Di Xie; Shangyuan Wang; Feng Chen; Shuming Pan
Journal:  J Inflamm Res       Date:  2021-08-06

4.  Inhibition of the Quorum Sensing System, Elastase Production and Biofilm Formation in Pseudomonas aeruginosa by Psammaplin A and Bisaprasin.

Authors:  Emmanuel T Oluwabusola; Nursheena Parveen Katermeran; Wee Han Poh; Teo Min Ben Goh; Lik Tong Tan; Oluwatofunmilayo Diyaolu; Jioji Tabudravu; Rainer Ebel; Scott A Rice; Marcel Jaspars
Journal:  Molecules       Date:  2022-03-06       Impact factor: 4.411

Review 5.  The Role of Pseudomonas aeruginosa Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction.

Authors:  Brant M Wagener; Ruihan Hu; Songwei Wu; Jean-Francois Pittet; Qiang Ding; Pulin Che
Journal:  Toxins (Basel)       Date:  2021-11-02       Impact factor: 5.075

Review 6.  Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis.

Authors:  Sheikh Mohammed Arif; R Andres Floto; Tom L Blundell
Journal:  Front Mol Biosci       Date:  2022-03-30

Review 7.  The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB.

Authors:  Virgyl Camberlein; Gwenaëlle Jézéquel; Jörg Haupenthal; Anna K H Hirsch
Journal:  Antibiotics (Basel)       Date:  2022-08-04
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.