Literature DB >> 33675526

ESCAPE-NA1 Trial Brings Hope of Neuroprotective Drugs for Acute Ischemic Stroke: Highlights of the Phase 3 Clinical Trial on Nerinetide.

Xin-Fu Zhou1.   

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Year:  2021        PMID： 33675526      PMCID： PMC8055737          DOI： 10.1007/s12264-020-00627-y

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


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  9 in total

1.  Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions.

Authors:  Michelle Aarts; Yitao Liu; Lidong Liu; Shintaro Besshoh; Mark Arundine; James W Gurd; Yu-Tian Wang; Michael W Salter; Michael Tymianski
Journal:  Science       Date:  2002-10-25       Impact factor: 47.728

Review 2.  Stroke research at the crossroads - where are we heading?

Authors:  Stefan Roth; Arthur Liesz
Journal:  Swiss Med Wkly       Date:  2016-07-11       Impact factor: 2.193

3.  Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain.

Authors:  Douglas J Cook; Lucy Teves; Michael Tymianski
Journal:  Nature       Date:  2012-02-29       Impact factor: 49.962

Review 4.  Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia.

Authors:  David W Howells; Michelle J Porritt; Sarah S J Rewell; Victoria O'Collins; Emily S Sena; H Bart van der Worp; Richard J Traystman; Malcolm R Macleod
Journal:  J Cereb Blood Flow Metab       Date:  2010-05-19       Impact factor: 6.200

5.  Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial.

Authors:  Michael D Hill; Renee H Martin; David Mikulis; John H Wong; Frank L Silver; Karel G Terbrugge; Geneviève Milot; Wayne M Clark; R Loch Macdonald; Michael E Kelly; Melford Boulton; Ian Fleetwood; Cameron McDougall; Thorsteinn Gunnarsson; Michael Chow; Cheemun Lum; Robert Dodd; Julien Poublanc; Timo Krings; Andrew M Demchuk; Mayank Goyal; Roberta Anderson; Julie Bishop; David Garman; Michael Tymianski
Journal:  Lancet Neurol       Date:  2012-10-08       Impact factor: 44.182

6.  Guidelines for Acute Ischemic Stroke Treatment.

Authors:  Shuwei Qiu; Yun Xu
Journal:  Neurosci Bull       Date:  2020-06-19       Impact factor: 5.203

7.  Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein.

Authors:  R Sattler; Z Xiong; W Y Lu; M Hafner; J F MacDonald; M Tymianski
Journal:  Science       Date:  1999-06-11       Impact factor: 47.728

8.  Preventing stroke: saving lives around the world.

Authors:  Kathleen Strong; Colin Mathers; Ruth Bonita
Journal:  Lancet Neurol       Date:  2007-02       Impact factor: 44.182

9.  Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.

Authors:  Michael D Hill; Mayank Goyal; Bijoy K Menon; Raul G Nogueira; Ryan A McTaggart; Andrew M Demchuk; Alexandre Y Poppe; Brian H Buck; Thalia S Field; Dar Dowlatshahi; Brian A van Adel; Richard H Swartz; Ruchir A Shah; Eric Sauvageau; Charlotte Zerna; Johanna M Ospel; Manish Joshi; Mohammed A Almekhlafi; Karla J Ryckborst; Mark W Lowerison; Kathy Heard; David Garman; Diogo Haussen; Shawna M Cutting; Shelagh B Coutts; Daniel Roy; Jeremy L Rempel; Axel Cr Rohr; Daniela Iancu; Demetrios J Sahlas; Amy Y X Yu; Thomas G Devlin; Ricardo A Hanel; Volker Puetz; Frank L Silver; Bruce C V Campbell; René Chapot; Jeanne Teitelbaum; Jennifer L Mandzia; Timothy J Kleinig; David Turkel-Parrella; Donald Heck; Michael E Kelly; Aditya Bharatha; Oh Young Bang; Ashutosh Jadhav; Rishi Gupta; Donald F Frei; Jason W Tarpley; Cameron G McDougall; Staffan Holmin; Joung-Ho Rha; Ajit S Puri; Marie-Christine Camden; Götz Thomalla; Hana Choe; Stephen J Phillips; Joseph L Schindler; John Thornton; Simon Nagel; Ji Hoe Heo; Sung-Il Sohn; Marios-Nikos Psychogios; Ronald F Budzik; Sidney Starkman; Coleman O Martin; Paul A Burns; Seán Murphy; George A Lopez; Joey English; Michael Tymianski
Journal:  Lancet       Date:  2020-02-20       Impact factor: 79.321
  9 in total
  5 in total

1.  Timely and Appropriate Administration of Inhaled Argon Provides Better Outcomes for tMCAO Mice: A Controlled, Randomized, and Double-Blind Animal Study.

Authors:  Juan He; Ke Xue; Jiayi Liu; Jin-Hua Gu; Bin Peng; Lihua Xu; Guohua Wang; Zhenglin Jiang; Xia Li; Yunfeng Zhang
Journal:  Neurocrit Care       Date:  2022-02-08       Impact factor: 3.532

Review 2.  Hypoxia Tolerant Species: The Wisdom of Nature Translated into Targets for Stroke Therapy.

Authors:  Carmen Del Río; Joan Montaner
Journal:  Int J Mol Sci       Date:  2021-10-15       Impact factor: 5.923

Review 3.  Metabolic Contribution and Cerebral Blood Flow Regulation by Astrocytes in the Neurovascular Unit.

Authors:  Shinichi Takahashi
Journal:  Cells       Date:  2022-02-25       Impact factor: 6.600

Review 4.  PSD-95: An Effective Target for Stroke Therapy Using Neuroprotective Peptides.

Authors:  Lola Ugalde-Triviño; Margarita Díaz-Guerra
Journal:  Int J Mol Sci       Date:  2021-11-22       Impact factor: 5.923

Review 5.  Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease.

Authors:  Shinichi Takahashi; Kyoko Mashima
Journal:  Antioxidants (Basel)       Date:  2022-01-17
  5 in total

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