Nasim Maleki1, Alan Finkel2, Guoshuai Cai3, Alexandra Ross4, R Davis Moore5, Xuesheng Feng6, X Michelle Androulakis7,8. 1. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA. 2. Carolina Headache Institute, 6114 Fayetteville Rd, Suite 109, Durham, NC, USA. 3. Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA. 4. University of South Carolina School of Medicine, Columbia, SC, 29209, USA. 5. Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA. 6. Navy Region Mid-Atlantic, Reserve Component Command, 1683 Gilbert Street, Norfolk, VA, 23511, USA. 7. University of South Carolina School of Medicine, Columbia, SC, 29209, USA. xiao.androulakis@va.gov. 8. Columbia VA Health Care System, Columbia, SC, 20208, USA. xiao.androulakis@va.gov.
Abstract
PURPOSE OF REVIEW: Post-traumatic headache (PTH) consequent to mild traumatic brain injury (mTBI) is a complex, multidimensional, chronic neurological disorder. The purpose of this review is to evaluate the current neuroimaging studies on mTBI and PTH with a specific focus on brain networks and connectivity patterns. RECENT FINDINGS: We present findings on PTH incidence and prevalence, as well as the latest neuroimaging research findings on mTBI and PTH. Additionally, we propose a new strategy in studying PTH following mTBI. The diversity and heterogeneity of pathophysiological mechanisms underlying mild traumatic brain injury pose unique challenges on how we interpret neuroimaging findings in PTH. Evaluating alterations in the intrinsic brain network connectivity patterns using novel imaging and analytical techniques may provide additional insights into PTH disease state and therefore inform effective treatment strategies.
PURPOSE OF REVIEW: Post-traumatic headache (PTH) consequent to mild traumatic brain injury (mTBI) is a complex, multidimensional, chronic neurological disorder. The purpose of this review is to evaluate the current neuroimaging studies on mTBI and PTH with a specific focus on brain networks and connectivity patterns. RECENT FINDINGS: We present findings on PTH incidence and prevalence, as well as the latest neuroimaging research findings on mTBI and PTH. Additionally, we propose a new strategy in studying PTH following mTBI. The diversity and heterogeneity of pathophysiological mechanisms underlying mild traumatic brain injury pose unique challenges on how we interpret neuroimaging findings in PTH. Evaluating alterations in the intrinsic brain network connectivity patterns using novel imaging and analytical techniques may provide additional insights into PTH disease state and therefore inform effective treatment strategies.
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