Hassan Sepehrmansourie1, Mahmoud Zarei2, Mohammad Ali Zolfigol3, Saeed Babaee1, Sadegh Rostamnia4,5. 1. Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 6517838683, Hamedan, Iran. 2. Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 6517838683, Hamedan, Iran. mahmoud8103@yahoo.com. 3. Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 6517838683, Hamedan, Iran. zolfi@basu.ac.ir. 4. Organic and Nano Group (ONG), Department of Chemistry, Iran University of Science and Technology (IUST), PO Box, 16846-13114, Tehran, Iran. rostamnia@iust.ac.ir. 5. Organic and Nano Group (ONG), Department of Chemistry, Faculty of Science, University of Maragheh, PO Box, 55181-83111, Maragheh, Iran. rostamnia@iust.ac.ir.
Abstract
Herein, a new magnetic metal-organic frameworks based on Fe3O4 (NMMOFs) with porous and high surface area materials were synthesized. Then, NMMOFs were characterized by FT-IR, XRD, SEM, elemental mapping, energy dispersive X-ray (EDS), TG, DTG, VSM, and N2 adsorption-desorption isotherms (BET). Fe3O4@Co(BDC)-NH2 as a magnetic porous catalyst was applied for synthesis of novel fused pyridines and 1,4-dihydropyridines with pyrazole and pyrimidine moieties as suitable drug candidates under ultrasonic irradiation. The significant advantages of the presented methodology are mild, facile workup, high yields, short reaction times, high thermal stability, and reusability of the described NMMOFs catalyst.
Herein, a new magnetic metal-organic frameworks based onn class="Chemical">Fe3O4 (NMMOFs) with porous and high surface area materials were synthesized. Then, NMMOFs were characterized by FT-IR, XRD, SEM, elemental mapping, energy dispersive X-ray (EDS), TG, DTG, VSM, and N2 adsorption-desorption isotherms (BET). Fe3O4@Co(BDC)-NH2 as a magnetic porous catalyst was applied for synthesis of novel fused pyridines and 1,4-dihydropyridines with pyrazole and pyrimidine moieties as suitable drug candidates under ultrasonic irradiation. The significant advantages of the presented methodology are mild, facile workup, high yields, short reaction times, high thermal stability, and reusability of the described NMMOFs catalyst.
Authors: Juan Amaro-Gahete; Rafael Klee; Dolores Esquivel; José Rafael Ruiz; César Jiménez-Sanchidrián; Francisco José Romero-Salguero Journal: Ultrason Sonochem Date: 2018-08-27 Impact factor: 7.491