| Literature DB >> 33674561 |
Xiaojiao Zheng1, Tianlu Chen1, Aihua Zhao1, Zhangchi Ning2,3, Junliang Kuang1, Shouli Wang1, Yijun You1, Yuqian Bao4, Xiaojing Ma4, Haoyong Yu4, Jian Zhou4, Miao Jiang5, Mengci Li1, Jieyi Wang1, Xiaohui Ma6, Shuiping Zhou6, Yitao Li2, Kun Ge1, Cynthia Rajani7, Guoxiang Xie7, Cheng Hu4, Yike Guo2, Aiping Lu8, Weiping Jia9,10, Wei Jia11,12,13.
Abstract
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict the development of metabolic disorders. We find in the first cohort (n = 1107) that both obesity and diabetes are associated with lower serum concentrations of HCA species. A separate cohort study (n = 91) validates this finding and further reveals that individuals with pre-diabetes are associated with lower levels of HCA species in feces. Serum HCA levels increase in the patients after gastric bypass surgery (n = 38) and can predict the remission of diabetes two years after surgery. The results are replicated in two independent, prospective cohorts (n = 132 and n = 207), where serum HCA species are found to be strong predictors for metabolic disorders in 5 and 10 years, respectively. These findings underscore the association of HCA species with diabetes, and demonstrate the feasibility of using HCA profiles to assess the future risk of developing metabolic abnormalities.Entities:
Year: 2021 PMID： 33674561 DOI： 10.1038/s41467-021-21744-w
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919