Literature DB >> 33674225

Uncloaking Breast Tumor Neoantigens with Radiation.

Jenna H Newman1, Nina Bhardwaj2.   

Abstract

Currently, immunotherapy is not effective for all cancer patients, partly due to an inability to mount sufficient tumor-specific T cell responses. Here, we highlight a recent study by Lhuillier et al. demonstrating that radiation potentiates neoantigen expression, eliciting CD4+ and CD8+ T cell responses and tumor growth control in mice.
Copyright © 2021 Elsevier Ltd. All rights reserved.

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Year:  2021        PMID： 33674225      PMCID： PMC8293833          DOI： 10.1016/j.it.2021.02.009

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  12 in total

Review 1.  Role of Local Radiation Therapy in Cancer Immunotherapy.

Authors:  Sandra Demaria; Encouse B Golden; Silvia C Formenti
Journal:  JAMA Oncol       Date:  2015-12       Impact factor: 31.777

2.  Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.

Authors:  Steven A Rosenberg; James C Yang; Richard M Sherry; Udai S Kammula; Marybeth S Hughes; Giao Q Phan; Deborah E Citrin; Nicholas P Restifo; Paul F Robbins; John R Wunderlich; Kathleen E Morton; Carolyn M Laurencot; Seth M Steinberg; Donald E White; Mark E Dudley
Journal:  Clin Cancer Res       Date:  2011-04-15       Impact factor: 12.531

3.  Antigenicity of murine skin tumors induced by ultraviolet light.

Authors:  M L Kripke
Journal:  J Natl Cancer Inst       Date:  1974-11       Impact factor: 13.506

4.  Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.

Authors:  Daniel K Wells; Marit M van Buuren; Kristen K Dang; Vanessa M Hubbard-Lucey; Kathleen C F Sheehan; Katie M Campbell; Andrew Lamb; Jeffrey P Ward; John Sidney; Ana B Blazquez; Andrew J Rech; Jesse M Zaretsky; Begonya Comin-Anduix; Alphonsus H C Ng; William Chour; Thomas V Yu; Hira Rizvi; Jia M Chen; Patrice Manning; Gabriela M Steiner; Xengie C Doan; Taha Merghoub; Justin Guinney; Adam Kolom; Cheryl Selinsky; Antoni Ribas; Matthew D Hellmann; Nir Hacohen; Alessandro Sette; James R Heath; Nina Bhardwaj; Fred Ramsdell; Robert D Schreiber; Ton N Schumacher; Pia Kvistborg; Nadine A Defranoux
Journal:  Cell       Date:  2020-10-09       Impact factor: 41.582

5.  Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control.

Authors:  Claire Lhuillier; Nils-Petter Rudqvist; Takahiro Yamazaki; Tuo Zhang; Maud Charpentier; Lorenzo Galluzzi; Noah Dephoure; Cristina C Clement; Laura Santambrogio; Xi Kathy Zhou; Silvia C Formenti; Sandra Demaria
Journal:  J Clin Invest       Date:  2021-03-01       Impact factor: 14.808

6.  Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer.

Authors:  Grit S Herter-Sprie; Shohei Koyama; Houari Korideck; Josephine Hai; Jiehui Deng; Yvonne Y Li; Kevin A Buczkowski; Aaron K Grant; Soumya Ullas; Kevin Rhee; Jillian D Cavanaugh; Neermala Poudel Neupane; Camilla L Christensen; Jan M Herter; G Mike Makrigiorgos; F Stephen Hodi; Gordon J Freeman; Glenn Dranoff; Peter S Hammerman; Alec C Kimmelman; Kwok-Kin Wong
Journal:  JCI Insight       Date:  2016-06-16

7.  A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

Authors:  B Lowin; F Beermann; A Schmidt; J Tschopp
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

8.  Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

Authors:  J W Heusel; R L Wesselschmidt; S Shresta; J H Russell; T J Ley
Journal:  Cell       Date:  1994-03-25       Impact factor: 41.582

9.  Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction.

Authors:  Shixiang Wang; Zaoke He; Xuan Wang; Huimin Li; Xue-Song Liu
Journal:  Elife       Date:  2019-11-26       Impact factor: 8.140

Review 10.  Computational Prediction and Validation of Tumor-Associated Neoantigens.

Authors:  Vladimir Roudko; Benjamin Greenbaum; Nina Bhardwaj
Journal:  Front Immunol       Date:  2020-01-24       Impact factor: 7.561
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