Literature DB >> 33673719

TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance.

Flaviana Marzano1, Mariano Francesco Caratozzolo1, Graziano Pesole1,2, Elisabetta Sbisà3, Apollonia Tullo1.   

Abstract

Colorectal cancer (CRC) represents one of the most widespread forms of cancer in the population and, as all malignant tumors, often develops resistance to chemotherapies with consequent tumor growth and spreading leading to the patient's premature death. For this reason, a great challenge is to identify new therapeutic targets, able to restore the drugs sensitivity of cancer cells. In this review, we discuss the role of TRIpartite Motifs (TRIM) proteins in cancers and in CRC chemoresistance, focusing on the tumor-suppressor role of TRIM8 protein in the reactivation of the CRC cells sensitivity to drugs currently used in the clinical practice. Since the restoration of TRIM8 protein levels in CRC cells recovers chemotherapy response, it may represent a new promising therapeutic target in the treatment of CRC.

Entities:  

Keywords:  CRC; TRIM8; chemoresistance; miR-17-5p

Year:  2021        PMID： 33673719      PMCID： PMC7997459          DOI： 10.3390/biomedicines9030241

Source DB:  PubMed          Journal:  Biomedicines        ISSN： 2227-9059


  263 in total

1.  TRIM25 has a dual function in the p53/Mdm2 circuit.

Authors:  P Zhang; S Elabd; S Hammer; V Solozobova; H Yan; F Bartel; S Inoue; T Henrich; J Wittbrodt; F Loosli; G Davidson; C Blattner
Journal:  Oncogene       Date:  2015-03-02       Impact factor: 9.867

2.  TRIM59 is a key regulator of growth and migration inrenal cell carcinoma.

Authors:  S-H Hu; M-J Zhao; W-X Wang; C-W Xu; G-D Wang
Journal:  Cell Mol Biol (Noisy-le-grand)       Date:  2017-05-20       Impact factor: 1.770

3.  Knockdown of TRIM47 inhibits breast cancer tumorigenesis and progression through the inactivation of PI3K/Akt pathway.

Authors:  Yaqiu Wang; Can Liu; Zhihui Xie; Hong Lu
Journal:  Chem Biol Interact       Date:  2020-01-22       Impact factor: 5.192

4.  TRIM24 as an independent prognostic biomarker for prostate cancer.

Authors:  Anne Offermann; Doris Roth; Marie Christine Hupe; Silke Hohensteiner; Finn Becker; Vincent Joerg; Jessica Carlsson; Christiane Kuempers; Julika Ribbat-Idel; Lars Tharun; Verena Sailer; Jutta Kirfel; Maria Svensson; Ove Andren; Verena Lubczyk; Rainer Kuefer; Axel S Merseburger; Sven Perner
Journal:  Urol Oncol       Date:  2019-06-07       Impact factor: 3.498

Review 5.  Revisiting STAT3 signalling in cancer: new and unexpected biological functions.

Authors:  Hua Yu; Heehyoung Lee; Andreas Herrmann; Ralf Buettner; Richard Jove
Journal:  Nat Rev Cancer       Date:  2014-11       Impact factor: 60.716

6.  Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells.

Authors:  Sophie Paquet-Fifield; Shir Lin Koh; Lesley Cheng; Laura M Beyit; Carolyn Shembrey; Christina Mølck; Corina Behrenbruch; Marina Papin; Meritxell Gironella; Sophie Guelfi; Ramona Nasr; Fanny Grillet; Michel Prudhomme; Jean-Francois Bourgaux; Antoni Castells; Jean-Marc Pascussi; Alexander G Heriot; Alain Puisieux; Melissa J Davis; Julie Pannequin; Andrew F Hill; Erica K Sloan; Frédéric Hollande
Journal:  Cancer Res       Date:  2018-03-06       Impact factor: 12.701

7.  Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion.

Authors:  Linlin Li; Lei Dong; Xiaotong Qu; Shi Jin; Xiupeng Lv; Guang Tan
Journal:  Int J Oncol       Date:  2016-02-17       Impact factor: 5.650

Review 8.  NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer.

Authors:  Yihui Fan; Renfang Mao; Jianhua Yang
Journal:  Protein Cell       Date:  2013-03-13       Impact factor: 14.870

9.  Tripartite motif containing 25 promotes proliferation and invasion of colorectal cancer cells through TGF-β signaling.

Authors:  Nianfeng Sun; Yu Xue; Ting Dai; Xiding Li; Nanxiang Zheng
Journal:  Biosci Rep       Date:  2017-07-12       Impact factor: 3.840

10.  An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

Authors:  Ningning Li; Roya Babaei-Jadidi; Federica Lorenzi; Bradley Spencer-Dene; Philip Clarke; Enric Domingo; Eugene Tulchinsky; Robert G J Vries; David Kerr; Yihang Pan; Yulong He; David O Bates; Ian Tomlinson; Hans Clevers; Abdolrahman S Nateri
Journal:  Oncogenesis       Date:  2019-02-19       Impact factor: 7.485
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  5 in total

1.  Tripartite motif 52 (TRIM52) promotes proliferation, migration, and regulation of colon cancer cells associated with the NF-κB signaling pathway.

Authors:  Yanjiao Guo; Yiming Zhou; Xiaodong Gu; Jianbin Xiang
Journal:  J Gastrointest Oncol       Date:  2022-06

2.  Clinical significance of TRIM29 expression in patients with gastric cancer.

Authors:  Javad Farhadi; Jamshid Mehrzad; Hassan Mehrad-Majd; Alireza Motavalizadehkakhky
Journal:  Gastroenterol Hepatol Bed Bench       Date:  2022

Review 3.  TRIM family contribute to tumorigenesis, cancer development, and drug resistance.

Authors:  Ning Huang; Xiaolin Sun; Peng Li; Xin Liu; Xuemei Zhang; Qian Chen; Hong Xin
Journal:  Exp Hematol Oncol       Date:  2022-10-19

Review 4.  Dissecting the Functional Role of the TRIM8 Protein on Cancer Pathogenesis.

Authors:  Jessica Elisabetta Esposito; Vincenzo De Iuliis; Francesco Avolio; Eliana Liberatoscioli; Riccardo Pulcini; Simona Di Francesco; Alfonso Pennelli; Stefano Martinotti; Elena Toniato
Journal:  Cancers (Basel)       Date:  2022-05-06       Impact factor: 6.575

Review 5.  Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity.

Authors:  Utsa Bhaduri; Giuseppe Merla
Journal:  Cells       Date:  2021-04-25       Impact factor: 6.600
  5 in total

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