| Literature DB >> 33673526 |
Yao-Tsung Yeh1,2, Sung-Chun Lin3, Gene-Hsiang Lee4, Zhi-Hong Wen5,6, Tsong-Long Hwang7,8,9,10, Yu-Jen Wu11, Jih-Jung Chen12, Lee-Shing Fang5,13,14, Mei-Kang Yuan15,16, Ping-Jyun Sung1,2,5,17,18.
Abstract
Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.Entities:
Keywords: Lobophytum crassum; X-ray; anti-inflammation; cembranoid; iNOS; lobocrassin; lobohedleolide
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Year: 2021 PMID： 33673526 PMCID： PMC7997245 DOI： 10.3390/md19030130
Source DB: PubMed Journal: Mar Drugs ISSN： 1660-3397 Impact factor: 5.118