Literature DB >> 33673054

Phenotypic Plasticity of Cancer Cells Based on Remodeling of the Actin Cytoskeleton and Adhesive Structures.

Svetlana N Rubtsova1, Irina Y Zhitnyak1, Natalya A Gloushankova1.   

Abstract

There is ample evidence that, instead of a binary switch, epithelial-mesenchymal transition (EMT) in cancer results in a flexible array of phenotypes, each one uniquely suited to a stage in the invasion-metastasis cascade. The phenotypic plasticity of epithelium-derived cancer cells gives them an edge in surviving and thriving in alien environments. This review describes in detail the actin cytoskeleton and E-cadherin-based adherens junction rearrangements that cancer cells need to implement in order to achieve the advantageous epithelial/mesenchymal phenotype and plasticity of migratory phenotypes that can arise from partial EMT.

Entities:  

Keywords:  E-cadherin; EMT; actin cytoskeleton; adherens junctions; cancer cells; migration; plasticity

Mesh：

Year:  2021        PMID： 33673054      PMCID： PMC7918886          DOI： 10.3390/ijms22041821

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  224 in total

1.  Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin.

Authors:  E Janda; M Nevolo; K Lehmann; J Downward; H Beug; M Grieco
Journal:  Oncogene       Date:  2006-06-05       Impact factor: 9.867

2.  Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis.

Authors:  Stéphane Romero; Christophe Le Clainche; Dominique Didry; Coumaran Egile; Dominique Pantaloni; Marie-France Carlier
Journal:  Cell       Date:  2004-10-29       Impact factor: 41.582

Review 3.  Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.

Authors:  Matthias Krause; Alexis Gautreau
Journal:  Nat Rev Mol Cell Biol       Date:  2014-09       Impact factor: 94.444

4.  L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers.

Authors:  Nancy Gavert; Alessia Vivanti; John Hazin; Thomas Brabletz; Avri Ben-Ze'ev
Journal:  Mol Cancer Res       Date:  2010-12-01       Impact factor: 5.852

5.  Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells.

Authors:  Tisheeka R Graham; Haiyen E Zhau; Valerie A Odero-Marah; Adeboye O Osunkoya; K Sean Kimbro; Mourad Tighiouart; Tongrui Liu; Jonathan W Simons; Ruth M O'Regan
Journal:  Cancer Res       Date:  2008-04-01       Impact factor: 12.701

6.  Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration.

Authors:  Jeremy S Logue; Alexander X Cartagena-Rivera; Michelle A Baird; Michael W Davidson; Richard S Chadwick; Clare M Waterman
Journal:  Elife       Date:  2015-07-11       Impact factor: 8.140

7.  Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway.

Authors:  Spencer C Wei; Laurent Fattet; Jeff H Tsai; Yurong Guo; Vincent H Pai; Hannah E Majeski; Albert C Chen; Robert L Sah; Susan S Taylor; Adam J Engler; Jing Yang
Journal:  Nat Cell Biol       Date:  2015-04-20       Impact factor: 28.824

8.  Epithelial cell adhesion molecule overexpression regulates epithelial-mesenchymal transition, stemness and metastasis of nasopharyngeal carcinoma cells via the PTEN/AKT/mTOR pathway.

Authors:  Meng-He Wang; Rui Sun; Xiao-Min Zhou; Mei-Yin Zhang; Jia-Bin Lu; Yang Yang; Li-Si Zeng; Xian-Zi Yang; Lu Shi; Ruo-Wen Xiao; Hui-Yun Wang; Shi-Juan Mai
Journal:  Cell Death Dis       Date:  2018-01-05       Impact factor: 8.469

Review 9.  The role of microtubules in the regulation of epithelial junctions.

Authors:  Ekaterina Vasileva; Sandra Citi
Journal:  Tissue Barriers       Date:  2018-11-05

10.  Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.

Authors:  Nicola Aceto; Aditya Bardia; David T Miyamoto; Maria C Donaldson; Ben S Wittner; Joel A Spencer; Min Yu; Adam Pely; Amanda Engstrom; Huili Zhu; Brian W Brannigan; Ravi Kapur; Shannon L Stott; Toshi Shioda; Sridhar Ramaswamy; David T Ting; Charles P Lin; Mehmet Toner; Daniel A Haber; Shyamala Maheswaran
Journal:  Cell       Date:  2014-08-28       Impact factor: 41.582
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  2 in total

Review 1.  Molecular neuropathology of brain-invasive meningiomas.

Authors:  Niklas von Spreckelsen; Christoph Kesseler; Benjamin Brokinkel; Roland Goldbrunner; Arie Perry; Christian Mawrin
Journal:  Brain Pathol       Date:  2022-03       Impact factor: 6.508

2.  Screening and cellular validation of prognostic genes regulated by super enhancers in oral squamous cell carcinoma.

Authors:  Liru Zhang; Huanju Li; Yongle Qiu; Yuanhang Liu; Xin Liu; Wenjing Wang
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269
  2 in total

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