| Literature DB >> 33672623 |
Julia A Gomes1,2,3,4, Eduarda Sgarioni1, Juliano A Boquett1,3, Ana Cláudia P Terças-Trettel5, Juliana H da Silva6, Bethânia F R Ribeiro7, Marcial F Galera8, Thalita M de Oliveira9, Maria Denise F Carvalho de Andrade10, Isabella F Carvalho11, Lavínia Schüler-Faccini1,2,3, Fernanda S L Vianna1,2,3,4,12.
Abstract
Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in utero exposed to ZIKV infection, but born without congenital anomalies, were evaluated. Children with CZS were predominantly infected by ZIKV in the first trimester (p < 0.001) and had mothers with lower educational level (p < 0.001) and family income (p < 0.001). We found higher risk of CZS due the allele rs2297518[A] of NOS2 (OR = 2.28, CI 95% 1.17-4.50, p = 0.015). T allele and TT/CT genotypes of the TNF rs1799724 and haplotypes associated with higher expression of TNF were more prevalent in children with CZS and severe microcephaly (p = 0.029, p = 0.041 and p = 0.030, respectively). Our findings showed higher risk of CZS due ZIKV infection in the first trimester and suggested that polymorphisms in NOS2 and TNF genes affect the risk of CZS and severe microcephaly.Entities:
Keywords: Zika virus; Zika virus infection; congenital abnormalities; disease susceptibility; genetic variation; genetic polymorphism; inflammation; maternal exposure; teratogens
Year: 2021 PMID： 33672623 DOI： 10.3390/v13020325
Source DB: PubMed Journal: Viruses ISSN： 1999-4915 Impact factor: 5.048