| Literature DB >> 33672325 |
Roberta Melchionna1, Paola Trono1,2, Annalisa Tocci1, Paola Nisticò1.
Abstract
Human tissues, to maintain their architecture and function, respond to injuries by activating intricate biochemical and physical mechanisms that regulates intercellular communication crucial in maintaining tissue homeostasis. Coordination of the communication occurs through the activity of different actin cytoskeletal regulators, physically connected to extracellular matrix through integrins, generating a platform of biochemical and biomechanical signaling that is deregulated in cancer. Among the major pathways, a controller of cellular functions is the cytokine transforming growth factor β (TGFβ), which remains a complex and central signaling network still to be interpreted and explained in cancer progression. Here, we discuss the link between actin dynamics and TGFβ signaling with the aim of exploring their aberrant interaction in cancer.Entities:
Keywords: TGFβ; actin cytoskeleton; actin-binding proteins; extracellular matrix; tumor microenvironment
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Year: 2021 PMID： 33672325 PMCID： PMC7926735 DOI： 10.3390/biom11020336
Source DB: PubMed Journal: Biomolecules ISSN： 2218-273X